NRx Pharmaceuticals, Inc.

NRX-100 may be available upon physician request when certain conditions are met
These conditions include the following:

• The patient has a serious or life-threatening illness or condition and is either no longer responsive to or not able to
tolerate any approved treatment option;

• The investigational drug is in active clinical development with sufficient data available to determine an appropriate
dose and schedule for the patient’s specific condition;

• A benefit-risk analysis, based on both the available clinical data as well as the requesting physician’s assessment of
the individual patient’s condition and history, supports making the investigational drug available;

• Making the investigational drug available will not negatively impact or delay the conduct of clinical trials or
regulatory review or approval of the investigational drug for broader patient access; and

• Adequate supply of the investigational drug is available.