Expanded access for participants with cancer with RET activation who are ineligible for an ongoing selpercatinib (also known as LOXO-292) clinical trial or have other considerations that prevent access to selpercatinib through an existing clinical trial. The treating physician/investigator contacts Lilly when, based on their medical opinion, a patient meets the criteria for inclusion in the expanded access program.
N/A for expanded access
Drug: Selpercatinib
Open-label expanded access
Other Name: LOXO-292
Other Name: LY3527723
Inclusion Criteria: - Diagnosis of cancer with RET activation, who are not eligible for an ongoing selpercatinib clinical trial and are medically suitable for treatment with selpercatinib - Have progressed or are intolerant to standard therapy, or no standard therapy option exists, or in the opinion of the investigator, are unlikely to derive significant clinical benefit from standard therapy - Have adequate organ function
Exclusion Criteria: - Currently enrolled in an ongoing clinical study of selpercatinib or another RET inhibitor - Clinically significant active cardiovascular disease or history of myocardial infarction within 6 months prior to study treatment; ongoing cardiomyopathy; or current prolongation of the QT interval corrected for heart rate using Fridericia's formula (QTcF) interval greater than 470 milliseconds
Cancer Treatment Centers of America
Goodyear, Arizona, 85338
Contact: 623-207-3000
Investigator: Ashish Sangal
Mayo Clinic of Scottsdale
Scottsdale, Arizona, 85259
Contact: 480-301-8000
Investigator: Nina J Karlin
City of Hope National Medical Center
Duarte, California, 91010-0269
Contact: 626-256-4673
Investigator: Erminia Massarelli
UCLA Medical Center
Los Angeles, California, 90095
Contact: 310-794-1816
Investigator: Mykola Onyshchenko
Kaiser Permanente
Oakland, California, 94612
Investigator: Jennifer Marie Suga
Irvine Medical Center
Orange, California, 92868
Contact: 714-456-8000
Investigator: Viola W Zhu
Kaiser Permanente Medical Center
Sacramento, California, 95814
Investigator: Jennifer Marie Suga
University of California - San Diego
San Diego, California, 92103
Contact: 858-534-2230
Investigator: Lyudmila Bazhenova
Kaiser Permanente Medical Center
San Francisco, California, 94115
Investigator: Jennifer Marie Suga
Univ of California San Francisco
San Francisco, California, 94115
Contact: 415-353-7552
Investigator: Alain Algazi
Kaiser Permanente
Santa Clara, California, 95051
Investigator: Jennifer Marie Suga
Kaiser Permanente Medical Center
Vallejo, California, 94589
Contact: 510-891-3414
Investigator: Jennifer Marie Suga
Memorial Cancer Institute
Hollywood, Florida, 33021
Contact: 305-243-1000
Investigator: Luis Raez
Mayo Clinic in Florida
Jacksonville, Florida, 32224
Contact: 904-953-2000
Investigator: Victor Bernet
Florida Hospital
Orlando, Florida, 32803
Contact: 407-303-0409
Investigator: Mark A Socinski
Tallahassee Memorial Cancer Center
Tallahassee, Florida, 32308
Contact: 850-431-5360
Investigator: Karen B. Russell
University Cancer and Blood Center
Athens, Georgia, 30607
Contact: 706-353-2990
Investigator: Petros G Nikolinakos
Emory University
Atlanta, Georgia, 30329-5102
Contact: 404-727-6123
Investigator: Taofeek Owonikoko
University of Chicago Medicine-Comprehensive Cancer Center
Chicago, Illinois, 60637
Contact: 630-862-5757
Investigator: Christine M Bestvina
Cancer Treatment Centers of America
Zion, Illinois, 60099
Contact: 847-872-6324
Investigator: Eugene R Ahn
Massachusetts General Hospital
Boston, Massachusetts, 02114
Contact: 617-726-2515
Investigator: Lori Wirth
Dana-Farber Cancer Institute
Boston, Massachusetts, 02215
Contact: 617-632-5869
Investigator: Geoffrey Oxnard
University of Michigan
Ann Arbor, Michigan, 48109
Contact: 734-647-8902
Investigator: Francis Worden
START Midwest
Grand Rapids, Michigan, 49546
Contact: 616-954-5554
Investigator: Nehal Lakhani
Mayo Clinic
Rochester, Minnesota, 55905
Contact: 507-284-4080
Investigator: John Morris
Comprehensive Cancer Centers of Nevada
Las Vegas, Nevada, 89169
Contact: 702-952-3400
Investigator: Fadi S Braiteh
Memorial Sloan Kettering Cancer Center
New York, New York, 10065
Contact: 646-888-4206
Investigator: Alexander Drilon
Cleveland Clinic Foundation
Cleveland, Ohio, 44195
Contact: 216-444-1128
Investigator: Nathan Pennell
Ohio State University Medical Center
Columbus, Ohio, 43210
Contact: 614-293-3873
Investigator: Manisha H Shah
Cancer Treatment Centers of America
Tulsa, Oklahoma, 74133
Contact: 918-286-5689
Investigator: Issam Alawin
University of Pennsylvania Hospital
Philadelphia, Pennsylvania, 19104
Contact: 215-898-8796
Investigator: Marcia Brose
Eastern Regional Medical Center
Philadelphia, Pennsylvania, 19124
Contact: 215-537-4555
Investigator: Arturo Loaiza-Bonilla
Oncology Consultants
Houston, Texas, 77030
Contact: 713-797-6323
Investigator: Julio A. Peguero
University of Texas MD Anderson Cancer Center
Houston, Texas, 77030
Contact: 713-745-6754
Investigator: Vivek Subbiah
Virginia Cancer Specialists
Fairfax, Virginia, 22031
Contact: 703-280-5390
Investigator: Alexander I Spira
University of Wisconsin-Madison Hospital and Health Clinic
Madison, Wisconsin, 53792-4108
Investigator: Mark Burkard
There may be multiple sites in this clinical trial. 1-877-CTLILLY (1-877-285-4559) or
1-317-615-4559
ClinicalTrials.gov@lilly.com
Contact Lilly at 1-800-LillyRx (1-800-545-5979)
Study Director
Eli Lilly and Company