Official Title
Expanded Access Study for the Treatment of Patients With Commercially Out-of-Specification Axicabtagene Ciloleucel
Brief Summary

The goal of this study is to provide access to axicabtagene ciloleucel for patientsdiagnosed with a disease approved for treatment with axicabtagene ciloleucel, that isotherwise out of specification for commercial release.

Detailed Description

Not Provided

Available
Treatment IND/Protocol
Large B-cell Lymphoma
Follicular Lymphoma

Drug: Axicabtagene Ciloleucel

A single infusion of chimeric antigen receptor (CAR)-transduced autologous T cells/kg
administered intravenously.
Other Name: Yescarta®

Eligibility Criteria

Inclusion Criteria:

- Have commercially manufactured axicabtagene ciloleucel that does not meet commercial
release criteria but does meet Kite clinical trial release criteria

- Females of childbearing potential must have a negative serum or urine pregnancy test
(females who have undergone surgical sterilization or who have been post-menopausal
for at least 2 years are not considered to be of childbearing potential)

- Deemed medically fit and stable to receive the product per the investigator's
evaluation

- Repeat leukapheresis is not feasible per the investigator's assessment

- Be diagnosed with 1 of the approved labeled indications for axicabtagene ciloleucel
that is intended for release

- In the investigator's opinion, there is no satisfactory alternative therapy
available to the individual

Exclusion Criteria:

- History of severe immediate hypersensitivity to any drugs or metabolites of similar
chemical classes as axicabtagene ciloleucel

- Uncontrolled active infection or inflammation per physician assessment

- Primary central nervous system lymphoma

Eligibility Gender
All
Eligibility Age
Minimum: 18 Years ~ Maximum: N/A
Countries
Japan
United States
Locations

University of Alabama at Birmingham
Birmingham, Alabama, United States

Banner MD Anderson Cancer Center
Gilbert, Arizona, United States

City of Hope Medical Center
Duarte, California, United States

Colorado Blood Cancer Institute
Denver, Colorado, United States

Mayo Clinic Florida
Jacksonville, Florida, United States

Winship Cancer Institute
Atlanta, Georgia, United States

Northside Hospital
Atlanta, Georgia, United States

St. Luke's Cancer Institute
Boise, Idaho, United States

Northwestern Memorial Hospital
Chicago, Illinois, United States

The University of Kansas Medical Center
Westwood, Kansas, United States

University of Maryland Cancer Center
Baltimore, Maryland, United States

Massachusetts General Hospital
Boston, Massachusetts, United States

Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States

Dana Farber Cancer Institute - Chestnut Hill
Boston, Massachusetts, United States

University of Michigan
Ann Arbor, Michigan, United States

Mayo Clinic
Rochester, Minnesota, United States

Washington University School of Medicine- Siteman Cancer Center
Saint Louis, Missouri, United States

University of Nebraska Medical Center
Omaha, Nebraska, United States

John Theurer Cancer Center at Hackensack University Medical Center
Hackensack, New Jersey, United States

Montefiore Medical Center (MMC)
Bronx, New York, United States

Roswell Park Cancer Institute
Buffalo, New York, United States

Weill Cornell Medicine - NewYork-Presbyterian Hospital
New York, New York, United States

Icahn School of Medicine at Mount Sinai
New York, New York, United States

UNC Hospitals, The University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States

Cleveland Clinic
Cleveland, Ohio, United States

The Ohio State University Wexner Medical Center- James Cancer Hospital
Columbus, Ohio, United States

Oregon Health & Science University
Portland, Oregon, United States

Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States

Fox Chase Cancer Center
Philadelphia, Pennsylvania, United States

UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, United States

Avera Cancer Institute
Sioux Falls, South Dakota, United States

Sarah Cannon Research Institute
Nashville, Tennessee, United States

Vanderbilt-Ingrim Cancer Center
Nashville, Tennessee, United States

Baylor University Medical Center
Dallas, Texas, United States

Houston Methodist Hospital
Houston, Texas, United States

The University of Texas MD Anderson Cancer Center
Houston, Texas, United States

Methodist Healthcare System of San Antonio dba Methodist Hospital
San Antonio, Texas, United States

Huntsman Cancer Institute, University of Utah
Salt Lake City, Utah, United States

Virginia Commonwealth University
Richmond, Virginia, United States

Fred Hutchinson Cancer Center
Seattle, Washington, United States

West Virginia University
Morgantown, West Virginia, United States

Medical College of Wisconsin
Milwaukee, Wisconsin, United States

Nagoya Medical Center
Aichi, Japan

Akita University Hospital
Akita, Japan

Tokyo Medical And Dental University Hospital
Bunkyo-ku, Japan

Chiba University Hospital
Chiba, Japan

Niigata University Medical & Dental Hospital
Chuo-ku, Japan

Ehime University Hospital
Ehime, Japan

Hamanomachi Hospital
Fukuokaken, Japan

Kyushu Medical Center
Fukuoka, Japan

Kyushu University Hospital
Fukuoka, Japan

Kurume University Hospital
Fukuoka, Japan

Gifu Municipal Hospital
Gifu, Japan

Gunma University Hospital
Gunma, Japan

Japanese Red Cross Kyoto Daiichi Hospital
Higashiyama-ku, Japan

Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital
Hiroshima, Japan

Hiroshima University Hospital
Hiroshima, Japan

Kobe University Hospital
Hyogo, Japan

Kobe City Medical Center General Hospital
Hyogo, Japan

Hyogo Medical University Hospital
Hyogo, Japan

University of Tsukuba Hospital
Ibaraki, Japan

Teikyo University Hospital
Itabashi-Ku, Japan

Kagawa University Hospital
Kagawa, Japan

Kagoshima University Hospital
Kagoshimaken, Japan

Kanazawa University Hospital
Kanazawa, Japan

Kokura Kinen Hospital
Kokurakita-ku, Japan

Kumamoto University Hospital
Kumamoto, Japan

University Hospital Kyoto Prefectural University of Medicine
Kyoto, Japan

Kyoto University Hospital
Kyoto, Japan

Mie University Hospital
Mie, Japan

Tohoku University Hospital
Miyagi, Japan

University of Miyazaki Hospital
Miyazaki City, Japan

Aichi Medical University Hospital
Nagakute, Japan

Shinshu University Hospital
Nagano, Japan

Nagasaki University Hospital
Nagasaki, Japan

Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital
Nagoya, Japan

Nagoya University Hospital
Nagoya, Japan

Univercity of the Ryukyus Hospital
Nakagami-gun, Japan

Oita University Hospital
Oita, Japan

Okayama University Hospital
Okayama, Japan

Kurashiki Central Hospital
Okayama, Japan

Osaka Red Cross Hospital
Osaka-shi, Japan

Osaka International Cancer Institute
Osaka, Japan

Osaka University Hospital
Osaka, Japan

Kansai Medical University Hospital
Osaka, Japan

Kindai University Hospital
Osaka, Japan

Jichi Medical University Saitama Medical Center
Saitama, Japan

Hokkaido University Hospital
Sapporo Hokkaido, Japan

Shiga University of Medical Science Hospital
Shiga, Japan

Shimane University Hospital
Shimane, Japan

Hamamatsu University Hospital
Shizuoka, Japan

Jichi Medical University Hospital
Tochigi, Japan

National Cancer Center Hospital
Tokyo, Japan

Toranomon Hospital
Tokyo, Japan

Jikei University Hospital
Tokyo, Japan

Juntendo University School of Medicine Juntendo Clinic
Tokyo, Japan

The University of Tokyo Hospital
Tokyo, Japan

Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital
Tokyo, Japan

Keio University Hospital
Tokyo, Japan

Nihon University Itabashi Hospital
Tokyo, Japan

Yamaguchi University Hospital
Ube City, Japan

Wakayama Medical University Hospital
Wakayama, Japan

Yamagata University Hospital
Yamagata, Japan

Yokohama City University Medical Center
Yokohama, Japan

Yokohama City University Hospital
Yokohama, Japan

Tottori Univeristy Hospital
Yonago-shi, Japan

Contacts

Medical Information
844-454-5483(1-844-454-KITE)
medinfo@kitepharma.com

Kite Study Director, Study Director
Kite, A Gilead Company

Kite, A Gilead Company
NCT Number
MeSH Terms
Lymphoma
Axicabtagene ciloleucel