Official Title
Quantitative Computed Tomography to Assess Ventilatory and Perfusion Abnormalities in Individuals with Post-Acute Sequelae of SARS-CoV-2 Infection
Brief Summary

Prospective cohort study to evaluate the utility of quantitative CT analysis to assessventilation and perfusion defects in patients with Post-acute Sequelae of SARS-CoV-2(PASC) and functional limitations

Detailed Description

This is a study to describe the overall pattern of lung ventilation and perfusion defects
in individuals with PASC. Subjects with PASC with a documented history of COVID-19 and
persistent symptoms of fatigue, dyspnea, and/or exercise intolerance will complete
questionnaires, and undergo pulmonary function tests, 6-minute walk tests, and a low dose
CT chest to describe the overall pattern of lung regional ventilation and blood
distribution and to compare this pattern to asymptomatic controls with and without prior
COVID-19.

Recruiting
Post-Acute COVID-19
Post COVID-19 Condition
Post Viral Fatigue
Dyspnea

Diagnostic Test: Computed Tomography of the Chest

Quantitative Computed Tomography of the chest in the inspiratory and expiratory phases
will be performed to assess regional lung ventilation as well as pulmonary vascular
volume and distribution

Eligibility Criteria

Inclusion Criteria:

- Age ≥ 18

- Self-reported or documented SARS-CoV-2 infection by RT-PCR or Antigen testing > 3
months ago or no previous history of SARS-CoV-2 infection (control group only)

- Normal or mild abnormalities on baseline Pulmonary Function Tests (PFTs)

- New or worsening symptoms of chronic fatigue, dyspnea or exercise intolerance after
COVID-19 with otherwise unclear etiology (PASC group only)

Exclusion Criteria:

- SARS-CoV-2 infection by RT-PCR or Antigen testing within the last 3 months

- Inability to provide consent or non-English speaking

- Pregnancy

- Any respiratory infection in last 4 weeks

- PFT relative contraindications

- History of major cardiovascular, pulmonary, renal, hepatic, autoimmune or
neuromuscular disease including asthma, COPD, interstitial lung disease, heart
failure, pulmonary arterial hypertension, or prior pulmonary embolism

- Active malignancy undergoing treatment or history of malignancy involving the lung

Eligibility Gender
All
Eligibility Age
Minimum: 18 Years ~ Maximum: 99 Years
Countries
United States
Locations

Tufts Medical Center
Boston, Massachusetts, United States

Investigator: Bipin Malla

Contacts

Not Provided

NCT Number
Keywords
Ventilation Perfusion Mismatch
MeSH Terms
COVID-19
Post-Acute COVID-19 Syndrome
Fatigue Syndrome, Chronic
Dyspnea