Objective: To analyze the structure, the vascular function, the vascular aging and the
determining factors in adults with a diagnosis of Persistent Covid and the differences by
gender.

Design: Cross-sectional descriptive observational study. Setting: The study will be
carried out at the Salamanca Primary Care Research Unit (APISAL). Study Subjects: The
study includes the basis of the Persistent Covid Monographic consultation in the Internal
Medicine Service of the University Hospital of Salamanca and the subjects with the
diagnosis of Persistent Covid in the MEDORA Primary Care clinical history. Thus, 300
subjects have been obtained who are diagnosed with Persistent Covid, who meet the
diagnostic criteria established by the Spanish Society of General and Family Physicians
and sign the informed consent.

Measurements: The variables reflected in the Integrated Assistance process for the Care
of People Affected by SARS CoV-2 of the Junta de Castilla y León will be collected, to
evaluate the functional status of the patient and persistent symptoms, their impact on
activities of daily life and quality of life of patients with Persistent Covid and the
perception of their health. Lifestyles (diet, physical activity, tobacco and alcohol),
psychological factors and cognitive impairment will be collected using validated
questionnaires, and physical activity will be objectively measured with a 7-day
pedometer. Vascular structure and function will be analyzed by measuring the thickness of
the carotid intima media (Sonosite Micromax); pulse wave analysis and carotid-femoral
pulse wave velocity (VOPcf) (Sphygmocor System). Cardio Ankle Vascular Index (CAVI),
ankle-brachial pulse wave velocity (VOPbt) and ankle-brachial index (Vasera VS-2000®).
Vascular aging will be calculated using the 10 and 90 percentiles of the VOPcf and the
VOPbt. Demographic, analytical variables and to assess retinal, cardiac, renal, cerebral
vascular lesion and cardiovascular risk will be collected.