The main objective of this research is to identify and characterize the differentmolecular variants of SARS-CoV-2, emerging and / or circulating in several countries ofSub-Saharan Africa (Burkina Faso, Côte d'Ivoire, Gabon, Mali, Chad and Republic of Congo)and determine their role in the evolution of the pandemic.
The main objective of this research is to identify and characterize the different
molecular variants of SARS-CoV-2, emerging and / or circulating in several countries of
Sub-Saharan Africa (Burkina Faso, Côte d'Ivoire, Gabon, Mali, Chad and Republic of Congo)
and determine their role in the evolution of the pandemic.
The research will combine retrospective and prospective approaches to determine the
evolutionary dynamics of the virus since the start of the pandemic. It is planned to
sequence the entire Spike protein gene for 1550 viruses and make 300 entire genomes. This
work will be supplemented by antibody seroneutralization and respiratory transcriptomics
tests, in order to estimate the immuno-virological response of the COVID-19 disease
associated with the identified SARS-CoV-2 variants.
Diagnostic Test: RT PCR
Characterize the different molecular variants of SARS-CoV-2, determine the escape
potential of the new variants from neutralization by monoclonal antibodies and currently
available vaccines and characterization of the mRNAs expressed in infected persons
Other Name: Sequencing of the S gene,Sequencing of the entire SARS-COV-2 genome,Seroneutralization of antibodies,Respiratory transcriptomics
Inclusion Criteria:
- Major subject (cf. country)
- Presenting for a SARS-COV-2 diagnosis, whether symptomatic or not
- Not objecting to participating in the research
Exclusion Criteria:
- NA
Centre de Référence pour les pathogènes émergents et réémergent
Bobo-Dioulasso, Burkina Faso
Centre Hospitalier Universitaire la Référence Nationale (CHU-RN)
N'Djamena, Chad
Laboratoire National de Santé Publique Brazzaville
Brazzaville, Congo
CIRBA
Abidjan, Côte D'Ivoire
Unité Mixte de Recherche CIRMF-SSM
Libreville, Gabon
SEREFO
Bamako, Mali
Not Provided