The prospective, longitudinal, open observational study monitors patients with cognitiveand neuropsychological symptoms after COVID-19 infection, in a longitudinal manner to seehow the disease has affected their physical, psychological and cognitive function, theirability to be active, return to work, their health-related quality of life in correlationwith potential diagnostic and prognostic markers.
The aim is to increase knowledge of the underlying biological processes; how biomarkers
correlate with degree of symptoms, mapping their role as diagnostic markers over time (24
months).
The investigators follow up to 100 study participants with post-acute sequelae of
SARS-CoV-2 infection (PASC) for 24 months, measure their physical, psychological and
neurocognitive symtoms and how they change over time (three visits: baseline, 12 months,
24 months) in correlation with biomarkers in blood, cerebrospinal fluid and faeces
samples as well as neuroradiological changes on MRI (baseline, 24 months).
Knowledge about the late effects of COVID-19 and its pathogenesis is still unknown. The
findings of the study can therefore be used as a guidance for future actions in
healthcare and, in the best case, can lead to a possible, either curative or
symptom-relieving, treatment.
Other: Follow-up
Follow-up of neurocognitive and psychiatric symptoms in Post COVID patients (baseline, 12
months, 24 months) in correlation with biomarkers using MRI, fMRI, neuropsychological
testing, lab samples (blood, CSF, microbiota).
Inclusion Criteria:
- neurocognitive symptoms after lab-verified COVID-19 infection
Exclusion Criteria:
- severe illness e.g cancer with a short expected survival time
- ongoing alcohol abuse
- ongoing drug abuse.
Department of Geriatrics, University Hospital Örebro
Örebro, Sweden
Yvonne Freund-Levi, MD, PhD, Principal Investigator
Medical Faculty, Örebro University, Dept of Geriatrics, USÖ