Official Title
Comparison of the Two-year Efficacy of Three Exercise Rehabilitation Strategies on Dyspnea in Patients Who Presented With Secondary Respiratory Distress Syndrome Secondary to Severe COVID-19 Pneumonia
Brief Summary

Dyspnea is defined by a subjective sensation of respiratory discomfort, the intensity ofwhich varies according to the terrain, the anamnesis and the cause. Resuscitation isassociated with many causes of dyspnea, including initial distress, mechanicalventilation, or after-effects following the pathology and its management.Respiratory distress is the most severe form of impaired lung function. It is the firstcause of hospitalization in intensive care. This distress, indicative of the failure ofthe respiratory system, is always severe and potentially fatal. It therefore constitutesan absolute therapeutic emergency. Dyspnea is often the revealing symptom of thecondition and the urgency surrounding its management is an additional factor of concernfor the patient. As a result, dyspnea is a pejorative element associated with severity oreven death.In patients surviving the initial condition, dyspnea persists and can be found months oreven years later, despite the initial rehabilitation. It is strongly associated withanxiety or even the fear of dying and contributes to the occurrence of post-traumaticstress syndromes. This persistent sensation of respiratory discomfort, limiting thepatient's autonomy in his activities of daily living, seems to be able to reduce hisquality of life. In addition, the perpetuation of this dyspnea could favor a spiral ofdeconditioning causing a progressive deterioration of the cardio-respiratory systemjustifying new hospitalizations.In patients with chronic respiratory failure, exercise rehabilitation supervised byhysiotherapists allows, in addition to improving autonomy, a significant reduction indyspnoea, thus increasing the quality of life of these patients.The main objective of this study is to evaluate the effect at 2 years of 3 modes ofmanagement of dyspnea: exercise rehabilitation, standard physiotherapy and "usual care"on post-resuscitation dyspnea in patients with presented with severe COVID-19.

Detailed Description

Not Provided

Recruiting
Dyspnea
COVID-19
Eligibility Criteria

Inclusion Criteria:

Patients in the RECOVER study (NCTT04569266):

- Patient ≥ 18 years old

- Patient meeting the inclusion criteria for this study (see appendix 1)

- Patient more than 2 years from their release from intensive care

- French-speaking patient

- Patient not objecting to their participation in this research

Usual care patients

- Patient ≥ 18 years old

- Patient having presented a respiratory infection by SARS-Cov-2 confirmed
biologically in the laboratory by PCR or any other commercial or public health test
or diagnosed by CT scan

- Patient who was under invasive mechanical ventilation during a stay in intensive
care in the center of Versailles for more than 48 consecutive hours following
infection by SARS-Cov-2 between 01/03/2020 and 26/01/2022

- Patient more than 2 years from their release from intensive care

- French-speaking patient

- Patient not objecting to their participation in this research

Exclusion Criteria:

- Patient under guardianship or curatorship

- Patient deprived of liberty

- Patient under legal protection

Eligibility Gender
All
Eligibility Age
Minimum: 18 Years ~ Maximum: N/A
Countries
France
Locations

Centre Hospitalier Victor Dupouy
Argenteuil, France

Fondation Hôpital Saint-Joseph
Paris, France

Hôpital Cochin
Paris, France

Centre Hospitalier André Mignot
Versailles, France

Contacts

Christophe ROMANET
144123085 - +33
cromanet@ghpsj.fr

François PHILIPPART, MD
144123085 - +33
fphilippart@ghpsj.fr

Christophe ROMANET, Study Director
Fondation Hôpital Saint-Joseph

Fondation Hôpital Saint-Joseph
NCT Number
MeSH Terms
COVID-19
Pneumonia
Respiratory Distress Syndrome
Respiratory Distress Syndrome, Newborn
Dyspnea