This prospective cohort study included 3053 pediatric patients who had been infected with
SARS-CoV-2 and developed fever, and scheduled to a surgery during March 2023 to August
2023.On the day of operation, the anesthesiologist in the children's operating room
conducted a preoperative evaluation. Upon confirming that general anesthesia was
appropriate, they proceeded to sign the informed consent for anesthesia. Three
anesthesiologists were assigned to the research group and conducted a second preoperative
visit to the children and their guardians in a separate room.

Body temperatures over 37.5 degrees Celsius was considered as fever. The time between
body temperature recovery and surgery was collected as categorical factor and was
scheduled to be analyzed in the following categories: 0-2 weeks; 3-4 weeks; 5-6 weeks;
7-8 weeks; And ≥ 3 months (control group). After entering the operating room, the
children were routinely monitored (pulse oxygen saturation-SpO2, blood pressure and
electrocardiogram). The anesthesia method and drug selection were decided by the
anesthesiologist in the operating room. The following data were collected and recorded:
age, height, weight and ASA classification; The preoperative medication and the
perioperative use of narcotic drugs ; The induction technique; The primary airway device;
The lowest value of SpO2 when the child entered the operating room, was intubated and was
extubated; PRAEs (such as cough, wheezing, laryngeal spasm and bronchial spasm) occurred
during operation; The treatment processwhen PRAEs occured; The total duration of
operation. The primary outcome was the incidence of intra-operative hypoxemia.