The aim of the study is to compare surgical outcomes (intra and post-operativecomplications) and sperm retrieval rates between conventional microsurgical-assistedtesticular sperm extraction (m-TeSE - Group A) and testicular sperm extraction performedwith surgical loupes (l-TeSE - Group B) in adult males with non-obstructive azoospermia.
Objective: To compare surgical outcomes and sperm retrieval rates (SRR) between
conventional microsurgical-assisted testicular sperm extraction (m-TeSE - Group A) and
testicular sperm extraction performed with surgical loupes (l-TeSE - Group B) in adult
males with non-obstructive azoospermia (NOA). A multicentric prospective randomized trial
was conducted from March 2022. Adult males with NOA without genetic alterations who
agreed to participate in the study and signed the required informed consent were
enrolled. SRR, intra and post-operative complications (according to Clavien-Dindo
classification), hormonal profile tchanges were considered as outcomes during the follow
up period.
Device: Microscope
The microscope provides a direct examination of the testicular parenchyma at 20-25x
magnification.
Device: Surgical loupes
Surgical loupes offer magnification of 3.5-5x.
Inclusion Criteria:
- Adult males
- Diagnosis of non obstructive azoospermia who required m-TeSE.
Exclusion Criteria:
- Absence of signed written informed consent
- Age < 18 years
- Obstructive azoospermia
- Genetic anomalies (e.g., Klinefelter syndrome, Kallmann syndrome, Y chromosome
microdeletions, CFTR mutations)
- Previous testicular biopsies/surgical sperm retrieval
- Personal history of malignant testicular tumor
- Unilateral cryptorchidism
- Varicocele
- Previous chemotherapy/radiotherapy treatments
- Monorchidism
Molinette - AOU Città della Salute e della Scienza di Torino
Turin 3165524, Italy
Not Provided