The omicron variant of coronavirus disease 2019 (COVID-19) has caused a global epidemicin 2022. The aim was to investigate the symptom spectrum and risk factors for fever inpediatric and adult patients with omicron infection. From April 8, 2022 to May 17, 2022,this prospective observational study included patients who attended the child-parentsections of the Fangcang shelter hospitals with laboratory-confirmed COVID-19. Patientdata were collected from questionnaires. The risk factors for prolonged fever and highfever were identified by univariate and multivariate analyses.
Study design and participants A prospective multicenter study was designed. It was
conducted in accordance with the Declaration of Helsinki (as revised in 2013). Informed
consent was obtained for all participants. From April 8, 2022 to May 17, 2022, Patients
who attended the child-parent sections of the Fangcang shelter hospitals in Shanghai,
China, with laboratory-confirmed COVID-19 were included. Those who had poor compliance
(defined as inability to comply with the protocol) were excluded. Data from the included
cases were collected. Adult patients and caregivers of children patients received two
kinds of questionnaires after admission. Type I questionnaire (supplemental material) for
basic characteristic were finished as soon as they were admitted. Type II questionnaire
(supplemental material) for symptom and medication use tracking were filled out every day
until discharge. This study was approved by the ethics committee of Shanghai Children's
Medical Center.
Definition of outcomes The outcomes were the likelihood of developing prolonged fever and
the likelihood of developing high fever. Fever was defined as temperature ≥ 38.0℃.
Prolonged fever was defined as fever for more than 2 days. High fever was defined as
temperature ≥ 39.1℃.
Statistical analysis SPSS version 25.0 (IBM SPSS Statistics, Armonk, NY, USA) was used to
analyze the data. Data are presented as median values and interquartile ranges (IQRs) for
continuous variables and frequencies and percentages for categorical variables. The
investigators used Mann-Whitney U test to compare continuous variables between two
groups. The investigators used χ2 test or Fisher exact test to compare categorical
variables. Univariable analysis was used to investigate the association of each clinical
variable with the outcomes. To determine the risk factors for each outcome, multivariable
analysis was performed by logistic regression with a stepwise variable model. Variables
of P value < 0.05 were candidates for multivariable analysis. Statistical significance
was determined as a 2-sided P value of < 0.05.
Other: observational questionnaires
Patient data were collected from questionnaires.
Inclusion Criteria:
- hospitalized in the child-parent sections of the Fangcang shelter hospitals in
Shanghai, China
- diagnosis of laboratory-confirmed COVID-19
Exclusion Criteria:
● have poor compliance (defined as inability to comply with the protocol)
child-parent sections of the Fangcang shelter hospitals
Shanghai 1796236, China
Not Provided