Inclusion Criteria:

- Participant must be 18 years of age or older at the time of signing the informed
consent.

- Weight ≥ 45 kg at Visit 1.

- Participants must satisfy at least 1 of the following risk factors at enrollment:

1. Obese, ie, BMI ≥ 30

2. Congestive heart failure

3. Chronic obstructive pulmonary disease

4. Chronic kidney disease

5. Intolerant of vaccine

6. Immunocompromised state (one of the following risk factors ):

1. Have cancer

2. Have solid organ transplant or a hematopoietic stem cell transplant

3. Are actively taking immunosuppressive medicines

4. Received chimeric antigen receptor T-cell therapy

5. Within 1 year of receiving B-cell depleting therapies

6. Have a moderate or severe primary immunodeficiency

- Medically stable

- WOCBP must not be pregnant or lactating and must use a highly effective method of
contraception

Exclusion Criteria:

- Known hypersensitivity to any component of the study intervention

- Previous hypersensitivity or severe adverse reaction following administration of a
mAb

- Acute or febrile infection prior to dosing

- Has HIV infection

- Receipt of any convalescent COVID-19 plasma treatment, mAb against SARS-CoV-2 ,
COVID-19 vaccine within 6 months

- COVID-19 antiviral prophylaxis within at least 2 weeks

- COVID-19 case within 6 months