Inclusion Criteria:

- over 18 years of age;

- with suspected squamous cell carcinoma of the oral cavity, oropharynx or
pharyngolarynx (any stage);

- with healthy, untreated contralateral mucosa and no contraindications to biopsy;

- with no history of any type of cancer;

- with a WHO performance status index of 0 to 2 inclusive ;

- able to receive treatment according to current European Society of Medical Oncology
guidelines ;

- without guardianship, curatorship or subordination;

- benefiting from a Social Security scheme or benefiting from one through a third
party;

- have given informed consent to participate in the study.

Exclusion Criteria:

- previously pre-treated in the ear, nose, throat sphere by radiotherapy or having
already received anti-cancer chemotherapy;

- on long-term immunosuppressive therapy, defined as taking an immunosuppresseur,
identified as such in the ATC classification, for 7 days, cortico-therapy >
7.5mg/day for more than 3 months, treatment or history of anti-CD20 treatment within
the year, or regular plasmatic exchange or gamma globulin infusion;

- benefiting from enhanced protection, i.e. minors, persons deprived of their liberty
by a judicial or administrative decision, persons staying in a health or social
establishment, adults under legal protection;

- pregnant or breast-feeding women of childbearing age (menopause must be documented
and more than 2 years old) who refuse or do not have an effective method of
contraception (hormonal/mechanical: oral, injectable, transcutaneous, implantable,
intrauterine device, or surgical: tubal ligation, hysterectomy, total oophorectomy)
for the duration of the study.

- final diagnosis of non-squamous cell carcinoma