Inclusion Criteria:

- Are hospitalized with pneumonia, and presumed or confirmed COVID-19

- Are able and willing to give signed informed consent (legally authorized
representative can provide informed consent if needed)

Exclusion Criteria:

- Female participants must not be pregnant and/or lactating

- Have Acute Respiratory Distress Syndrome (ARDS) or will require immediate intermittent
mandatory ventilation (IMV), or are ineligible for IMV

- Have any concurrent serious medical condition (for example dialysis) or concomitant
medication that would preclude participation in the study

- Are moribund irrespective of the provision of treatments

- Have a known history or show evidence of human immunodeficiency virus (HIV) and/or
hepatitis

- Have recently undergone major surgery or central venous access device placement

- Have a significant bleeding disorder or active vasculitis

- Have experienced a thromboembolic event

- Have symptomatic congestive heart failure, or symptomatic or poorly controlled cardiac
arrhythmia

- Have a serious, nonhealing wound, peptic ulcer, or bone fracture

- Have liver cirrhosis

- Have a known sensitivity to monoclonal antibodies (mAbs) or other therapeutic proteins

- Have a history of hypertensive crisis or hypertensive encephalopathy or current,
poorly controlled hypertension