Official Title
A Randomized, Double-blind, Placebo-controlled, Clinical Trial of LY3127804 in Patients Who Are Hospitalized With Pneumonia and Presumed or Confirmed COVID-19
Brief Summary

A randomized, double-blind, placebo-controlled, clinical trial of LY3127804 in participants who are hospitalized with pneumonia and presumed or confirmed COVID-19.


Drug: LY3127804

Administered IV

Drug: Placebo

Administered IV

Eligibility Criteria

Inclusion Criteria:

- Are hospitalized with pneumonia, and presumed or confirmed COVID-19

- Are able and willing to give signed informed consent (legally authorized
representative can provide informed consent if needed)

Exclusion Criteria:

- Female participants must not be pregnant and/or lactating

- Have Acute Respiratory Distress Syndrome (ARDS) or will require immediate intermittent
mandatory ventilation (IMV), or are ineligible for IMV

- Have any concurrent serious medical condition (for example dialysis) or concomitant
medication that would preclude participation in the study

- Are moribund irrespective of the provision of treatments

- Have a known history or show evidence of human immunodeficiency virus (HIV) and/or

- Have recently undergone major surgery or central venous access device placement

- Have a significant bleeding disorder or active vasculitis

- Have experienced a thromboembolic event

- Have symptomatic congestive heart failure, or symptomatic or poorly controlled cardiac

- Have a serious, nonhealing wound, peptic ulcer, or bone fracture

- Have liver cirrhosis

- Have a known sensitivity to monoclonal antibodies (mAbs) or other therapeutic proteins

- Have a history of hypertensive crisis or hypertensive encephalopathy or current,
poorly controlled hypertension

Eligibility Gender
Eligibility Age
Minimum: 18 Years ~ Maximum: N/A
United States

Banner Univ Med Ctr Phoenix
Phoenix, Arizona, United States

Banner Univ Med Ctr Tucson
Tucson, Arizona, United States

National Jewish Medical and Research Center
Denver, Colorado, United States

Nuvance Danbury Hospital
Danbury, Connecticut, United States

NorthShore University HealthSystem
Evanston, Illinois, United States

Parkview Research Center
Fort Wayne, Indiana, United States

Franciscan St. Francis Health
Indianapolis, Indiana, United States

Ochsner Clinic Foundation
New Orleans, Louisiana, United States

Lahey Hospital and Medical Center
Burlington, Massachusetts, United States

Henry Ford Hospital Detroit
Detroit, Michigan, United States

Allina Hospital Network
Minneapolis, Minnesota, United States

State University of New York Hospital
Syracuse, New York, United States

East Carolina University
Greenville, North Carolina, United States

Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST), Study Director
Eli Lilly and Company

Eli Lilly and Company
NCT Number
Corona Virus Disease 19 (COVID-19)
2019 Novel Coronavirus (2019 n-COV)
Severe Acute Respiratory Syndrome (SARS)
Pulmonary Disease
MeSH Terms