Inclusion:

- Male and female participants aged from 18 years old or older at screening who are
overtly healthy as determined by medical evaluation including medical history,
physical examination, laboratory tests, and ECG.

- BMI of 16-32 kg/m2 (both inclusive); and a total body weight >45 kg (99 lbs.).

- Chinese male and female participants are defined as individuals currently residing
in mainland China who were born in China and have both parents of Chinese descent.

Exclusion:

- Evidence or history of clinically significant hematological, renal, endocrine,
pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurological, or
allergic disease (including drug allergies, but excluding untreated, asymptomatic,
seasonal allergies at the time of dosing).

- Any condition possibly affecting drug absorption (e.g., gastrectomy,
cholecystectomy).

- History of HIV infection, hepatitis B, or hepatitis C; positive testing for HIV,
HBsAg, or HCVAb. Hepatitis B vaccination is allowed.

- Any medical or psychiatric condition including recent (within the past year) or
active suicidal ideation/behavior or laboratory abnormality or other conditions that
may increase the risk of study participation or, in the investigator's judgment,
make the participant inappropriate for the study.

- Use of prescription or nonprescription drugs and dietary and herbal supplements
within 7 days or 5 half-lives (whichever is longer) prior to the first dose of study
intervention.

- Previous administration of an investigational product (drug or vaccine) within 30
days or 5 half-lives preceding the first dose of study intervention used in this
study (whichever is longer). Participation in studies of other investigational
products (drug or vaccine) at any time during participation in this study.

- A positive urine drug test. A single repeat for positive drug screen may be allowed.

- Pregnant or breastfeeding women.

- Screening supine BP ≥140 mm Hg (systolic) or ≥90 mm Hg (diastolic) for participants
<60 years; and ≥150/90 mm/Hg for participants ≥60 years old, following at least 5
minutes of supine rest. If systolic BP is ≥140 or 150 mm Hg (based on age) or
diastolic ≥90 mm Hg, the BP should be repeated 2 more times, and the average of the
3 BP values should be used to determine the participant's eligibility.

- Standard 12-lead ECG that demonstrates clinically relevant abnormalities that may
affect participant safety or interpretation of study results (e.g., QTcF >450 ms,
complete LBBB, signs of an acute or indeterminate- age myocardial infarction, ST
segment and/or T wave changes suggestive of myocardial ischemia, second- or third-
degree AV block, or serious bradyarrhythmia or tachyarrhythmias). If QTcF exceeds
450 ms, or QRS exceeds 120 ms, the ECG should be repeated twice and the average of
the 3 QTcF or QRS values used to determine the participant's eligibility.
Computer-interpreted ECGs with abnormal findings should be overread by a physician
experienced in reading ECGs before excluding a participant.

- Participants with ANY of the following abnormalities in clinical laboratory tests at
screening, as assessed by the study-specific laboratory and confirmed by a single
repeat test, if deemed necessary: ALT, AST, Bilirubin ≥1.5× ULN