The purpose of this study is to learn about the safety, tolerability, and immunogenicityof an updated vaccine against COVID-19, called BNT162b2 (2025/2026 formulation).This study is seeking participants 5 through 11 years of age who: - have at least 1 underlying condition that puts them at high risk for severe outcomes from COVID-19, - and are medically stable.All participants in this study will receive 1 vaccine dose given in the muscle of theirarm of a BNT162b2 (2025/2026 formulation) vaccine which targets the COVID-19 virus,specifically the strain selected for the 2025-2026 COVID-19 viral respiratory season.Participants will take part in this study for about 6 months and will need to visit theclinical study site at least 2 times.
Not Provided
Biological: BNT162b2 (2025/2026 formulation)
BNT162b2 (formulation targeting the 2025/2026 recommended SARS-CoV-2 strain)
Key Inclusion Criteria:
- Children 5 through 11 years of age at their first appointment.
  -  Children with at least 1 underlying stable medical condition that increases their
     risk of severe COVID-19, as listed in the protocol.
Key Exclusion Criteria:
- Children who have had confirmed COVID-19 within the last 5 months (150 days).
  -  Children who have received a COVID-19 vaccine, either as part of a research study or
     an approved vaccine, within the last 5 months (150 days).
- Children who have received a 2025-2026 seasonal COVID-19 vaccination.
- Children with a history of myocarditis or pericarditis.
  -  Children with a previous or current diagnosis of Multisystem Inflammatory Syndrome
     in Children (MIS-C)
  -  Children with a medical condition wherein they would be considered for a second dose
     of COVID-19 vaccine to protect against risk of severe COVID-19 based on standard of
     care.
Refer to the study contact for further eligibility details.
C & R Research USA
Homestead	4159050, Florida	4155751, United States
Florida Pharmaceutical Research and Associates
Miami	4164138, Florida	4155751, United States
J. Lewis Research, Inc. / Foothill Family Clinic
Salt Lake City	5780993, Utah	5549030, United States
J. Lewis Research, Inc. / Foothill Family Clinic South
Salt Lake City	5780993, Utah	5549030, United States
Pfizer CT.gov Call Center
1-800-718-1021
ClinicalTrials.gov_Inquiries@pfizer.com
Pfizer CT.gov Call Center, Study Director
 Pfizer