Inclusion Criteria:

1. Male or female aged ≥18 years when signing ICF;

2. For Cohort 1: Participants who have not been vaccinated with any COVID-19 vaccine;
For Cohort 2: Participants who were fully vaccinated with 2 or 3 doses of
inactivated COVID-19 vaccine and the interval between the last dose of previously
vaccination and the 1st study vaccination is 3 to 24 months;

3. Healthy participants or participants with pre-existing medical conditions that are
in stable condition. The "pre-existing medical conditions" include but not limited
to hypertension, diabetes, chronic cholecystitis and cholelithiasis, chronic
gastritis, etc. A stable medical condition is defined as disease not requiring
significant change in therapy or hospitalization as a consequence of worsening
disease state for at least 3 months prior to study participation;

4. The participant or his/her legal representative can sign written ICF, and can fully
understand the trial procedure, the risk of participating in the trial, and other
interventions that are available if they do not participate in the trial;

5. The participant can read, understand, and fill in record cards by himself/herself or
with help;

6. Fertile men and women of childbearing potential voluntarily agree to take effective
contraceptive measures from signing ICF to 6 months after the last dose of study
vaccination.

Exclusion Criteria:

1. Presence of fever (oral temperature ≥37.5℃) within 3 days before the 1st study
vaccination;

2. For Cohort 2 only: Known history of COVID-19 or asymptomatic SRAS-CoV-2 infection;

3. A history of allergic reactions to any vaccines or drugs, such as allergy,
urticaria, severe skin eczema, dyspnea, laryngeal edema, and angioneurotic edema;

4. Immunocompromised patients suffering from immunodeficiency diseases, significant
diseases, or immune diseases (including Guillain-Barre Syndrome [GBS], systemic
lupus erythematosus, rheumatoid arthritis, asplenia or splenectomy caused by any
circumstances, and other immune diseases that may have an impact on immune response
in the investigator's opinion), etc;

5. Long-term use of immunosuppressant therapy or immunomodulatory drugs for >14 days
within the six months prior to enrollment. Whereas short-term (≤14 days) use of
oral, inhaled and topical steroids are allowed;

6. Those who have a history of HIV or tested positive for HIV;

7. For Cohort 1, participants received any drugs or vaccines used to prevent COVID-19;
for Cohort 2, participants received other drugs or vaccines used to prevent COVID-19
besides inactivated COVID-19 vaccines;

8. A history of Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory
Syndrome (MERS), or related vaccination;

9. A medical or family history of seizure, epilepsy, encephalopathy and psychosis;

10. Presence of severe or uncontrollable cardiovascular diseases, or severe or
uncontrollable disorders related to endocrine system, blood and lymphatic system,
liver and kidney, respiratory system, metabolic and skeletal systems, or
malignancies (skin basal cell carcinoma and carcinoma in-situ of cervix are
exceptions and will not be excluded), such as severe heart failure, severe pulmonary
heart disease, unstable angina, liver failure, or uremia;

11. Contraindications for intramuscular injection or intravenous blood sampling,
including thrombocytopenia and other blood coagulation disorders;

12. Patients on antituberculosis therapy;

13. Participants who received any immunoglobulin or blood products in the previous 3
months before enrollment, or plan to receive similar products during the study;

14. Participants who received other investigational drugs within 1 month before the
study vaccination;

15. Participants who have acute illness, such as acute onset of chronic heart failure,
acute sore throat, hypertensive encephalopathy, acute pneumonia, acute renal
insufficiency, acute cholecystitis;

16. Participants vaccinated with influenza vaccine within 14 days or with other vaccines
within 28 days before the study vaccination;

17. Those who donated blood or had blood loss (≥450 mL) within 3 months before the
vaccination or plan to donate blood during the study period;

18. Those who are pregnant or breast-feeding or plan to be pregnant during the study
period;

19. Those who plan to donate ovum or sperms during the study period;

20. Those who cannot follow the trial procedures, or cannot cooperate to complete the
study due to planned relocation or long-term outing;

21. Those unsuitable for participating in the clinical trial as determined by the
investigator because of other abnormalities that are likely to confuse or confound
the study results, or non-conformance with the maximal benefits of the participants.