Inclusion Criteria:

Subprotocol 1:

- ≥65 years of age at the time of signing the informed consent or ≥12 to <65 years of
age at the time of signing the informed consent with at least 1 risk factor for
severe outcomes from COVID-19.

- Investigator's assessment that the participant understands and is willing and
physically able to comply with protocol-mandated follow-up, including all
procedures.

- Participants who are assigned female at birth or could become pregnant:

i) Has a negative pregnancy test at the Screening Visit and on the day of
vaccination prior to vaccine dose being administered on Day 1.

ii) Has practiced adequate contraception or has abstained from all activities that could
result in pregnancy for at least 28 days prior to the first dose (Day 1).

iii) Has agreed to continue adequate contraception through 28 days following vaccine
administration.

Exclusion Criteria:

Subprotocol 1:

- History of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
within 6 months prior to enrollment.

- Acutely ill or febrile (temperature ≥38.0°Celsius/≥100.4°Fahrenheit) within 72 hours
prior to or at the Screening Visit or Day 1. Participants meeting this criterion may
be rescheduled within the Screening window and will retain their initially assigned
participant number.

- History of a diagnosis or condition that, in the judgment of the Investigator, is
clinically unstable or may affect participant safety, assessment of study endpoints,
assessment of immune response, or adherence to study procedures.

- Receipt of the COVID-19 vaccine within 6 months prior to enrollment.

- Receipt of any licensed non-COVID-19 vaccine within 28 days before or planned
receipt within 28 days after the study intervention, except an influenza vaccine,
which may be given 14 days before or after receipt of the study intervention.

- Receipt of systemic immunosuppressants for >14 days in total, within 180 days prior
to Screening Visit (for corticosteroids ≥10 milligrams [mg]/day of prednisone
equivalent) or is anticipating the need for immunosuppressive treatment at any time
during participation in the study.

- Receipt of systemic immunoglobulins, long-acting biological therapies that affect
immune responses (for example, infliximab) or blood products within 90 days prior to
the Screening Visit or plans to receive them during the study.

- History of anaphylaxis or severe hypersensitivity reaction requiring medical
intervention after receipt of any mRNA vaccine or therapeutic or any components of
an mRNA vaccine or therapeutic.

- Has donated ≥450 milliliters (mL) of blood products within 28 days prior to the
Screening Visit or plans to donate blood products within 28 days after the study
injection.

Note: Other protocol-specified inclusion and exclusion criteria may apply.