The Covid19 pandemic, paradoxically, represents a valuable opportunity to carry outcohort studies that allow us to advance our knowledge about the relationship betweeninflammation, brain development and an increased risk of suffering from neuropsychiatricdisorders or alterations. In addition, the current availability of sophisticatedbiological techniques and evaluation procedures represents an unique option for thispurpose.Here, we propose a cohort study of sars-cov-2 (type 2 coronavirus causing severe acuterespiratory syndrome) infected pregnant women and newborns. We will try to answer thefollowing questions: (i) what is the inflammatory / immune status of newborns (NBs) ofmothers infected by Covid19 like?; (ii) is there a relationship between the clinicalcharacteristics of the maternal infection (severity / moment / of infection) and theinflammatory status of the newborn?; (iii) could these features increase thevulnerability to developing central nervous system (CNS) alterations at an early age, andat some point during adult life ?; (iv) How is the Covid19 infected mother's placentaaltered? Do the placental alterations Covid19 mediated contribute to develop CNSalterations?; (v) is the infection associated with phenotypes obtained throughneurological and neurodevelopmental clinical evaluation (hypotonia, clumsiness, impairedcommunication and sociability) in children at 6 months and 12 months?Our main objective is to explore how the presence of stressors and prenatal sars-cov-2infection generates an abnormal inflammatory activity in the newborn, which is associatedwith neurodevelopmental disorders and which confers a greater risk of developingneuropsychiatric disorders. The biological information of the umbilical cord (fetusblood) and peripheral blood of the mother obtained after childbirth was provided by thecohort of women during the Covid19 pandemic monitored during their pregnancy, delivery,childbirth and postpartum. These samples and the clinical characterisation of the cohortof mothers and newborns, of which we will be able to do an exhaustive longitudinalfollow-up, are tremendously valuable at this time. There is a need to establish newresearch strategies to understand the pathophysiology of neuropsychiatric diseases, andto discover new molecular and cellular mechanisms involved in the development of the CNS.