Even though the COVID-19 pandemic is no longer at its peak, the threat still lingers.Engaging in prospective surveillance studies will enable us to monitor the disease andprepare for any potential resurgence. COVID-19 surveillance studies are essential toolsfor policymakers to make informed decisions, allocate resources, and develop strategiesto control the spread of the virus and protect public health.The objective of this surveillance study is to prospectively assess in-hospital severemorbidity related to COVID-19 infection in children who present to the PediatricEmergency Department (ED).A prospective multicenter study will be conducted across eight EDs in Israel and five EDsin the United Kingdom. The study population will include children aged 16 years oryounger with a severe acute COVID-19 infection. Confirmation of acute COVID-19 infectionwill be based on polymerase chain reaction nasopharyngeal swab testing. The study willalso include patients diagnosed with multisystem inflammatory syndrome in children(MIS-C), as defined by the CDC.