Official Title
Seroprevalence of SARS-Cov-2 Antibodies in Children - a Prospective Multicentre Cohort Study
Brief Summary

It is unknown what proportion of healthy children have been exposed to SARS-Cov-2 and how many have antibodies. The aim of this study is to follow a cohort of healthy children over six months and measure their antibodies to SARS-CoV-2.

Detailed Description

Coronaviruses are non-segmented positive-stranded RNA viruses with a roughly 30 kb genome.

The majority of coronaviruses cause disease in a specific host species but some have infected

humans by cross-species transmission. This process has led to a number of severe outbreaks of

human disease including severe acute respiratory syndrome (SARS) in 2003 and Middle East

respiratory syndrome (MERS) in 2012.



From December 2019 a novel infection "severe acute respiratory syndrome coronavirus 2"

(SARS-CoV-2) was identified in the Wuhan region of China. The infection was identified as the

causal factor in a growing number of severe cases of pneumonia. This disease was subsequently

named coronavirus disease 2019 (COVID-19) by World Health Organisation (WHO). SARS-CoV-2 has

been shown to cause severe disease similar to the previous SARS coronavirus from 2003. Severe

disease is associated with pneumonia and damage to vital organs including lung, heart, liver,

and kidney.



Fortunately SARS-CoV-2 appears to cause only mild, or no, symptoms in children.



The social distancing measures in the United Kingdom include the closure of schools and the

cancelling of routine paediatric clinics. These drastic, but necessary, steps are likely to

have a profound effect on the well-being of children.



This study is required to determine what proportion of children have been exposed to

SARS-Cov-2 and how many, if any, have neutralizing antibodies. The findings from this study

could be used to inform public health decisions regarding the re-opening of schools and other

services vital to the well-being of children.

Recruiting
COVID
Corona Virus Infection

Diagnostic Test: Covid-19 Antibody testing (IgG and IgM)
Antibody testing for previous exposure to Covid-19
Healthy Children

Eligibility Criteria

Healthy children of healthcare professionals.

Exclusion Criteria:

Not currently receiving antibiotics, not admitted to hospital within the last seven days,
not receiving immunosuppressive drugs and never diagnosed with a malignancy.

Eligibility Gender
All
Eligibility Age
Minimum: 2 Years~Maximum: 15 Years
Countries
United Kingdom
Contacts

Thomas Waterfield, BMBCh
07872990521
t.waterfield@qub.ac.uk

Sharon Christie, PhD
07899913551
sharon.christie@belfasttrust.hscni.net

Thomas Waterfield, BMBCh
Principal Investigator
Queen's University, Belfast

Queen's University, Belfast
Belfast Health and Social Care Trust
NCT Number
Keywords
Antibodies
MeSH Terms
Coronavirus Infections
Severe Acute Respiratory Syndrome
Antibodies