Inclusion Criteria:

- Patients diagnosed with COVID-19

- Aged between 18-75 years;

- Willing to sign the informed consent voluntarily.

Exclusion Criteria:

- Patients with active tuberculosis, idiopathic pulmonary fibrosis, bronchial asthma,
bronchiectasis, pulmonary embolism, chronic respiratory failure or other serious
respiratory diseases; ② patients with serious cardiovascular and cerebrovascular
diseases (malignant arrhythmia, unstable angina, acute myocardial infarction, cardiac
function grade 3 or above, stroke, cerebral hemorrhage, etc.); ③ Patients with serious
hepatorenal diseases (serious liver diseases refer to cirrhosis, portal hypertension
and varicose bleeding, and serious kidney diseases include dialysis and kidney
transplantation); ④ tumor patients who have undergone resection, radiotherapy and
chemotherapy within 5 years; ⑤ patients who have difficulty in activity due to
neuromuscular diseases; ⑥ patients with serious arthritis; ⑦ patients with serious
peripheral vascular diseases; ⑧ Pregnant and lactating women; ⑨ with severe cognitive
and mental disorders; ⑩ the clinical researchers who were participating in other
interventions within one month before selection;