The project is designed as a cross-sectional study and aims to examine long-termconsequences of coronavirus disease 2019 (COVID-19) for selected bio-behaviouralparameters while taking the disease course severity into account.
Not Provided
Diagnostic Test: Cardiorespiratory fitness
Cardiopulmonary exercise testing
Diagnostic Test: Lung function
Body plethysmography
Diagnostic Test: Muscular strength and balance tests
Handgrip strength test, mid-thigh pull test and standing balance test in static tandem
stance
Diagnostic Test: Micro- and macrovascular endothelial function and cardiac function
Measurement of flow-mediated dilation, static and dynamic retinal vessel analysis,
echocardiography
Diagnostic Test: Blood sampling and analysis
Blood sampling by venepuncture
Diagnostic Test: Physical activity
Physical activity surveillance using accelerometers
Diagnostic Test: Questionnaires
Global physical activity questionnaire (GPAQ), short-form 8 health survey (SF-8),
barriers to physical activity, fatigue assessment scale (FAS), modified medical research
council dyspnea scale (mMRC), depression, anxiety, and stress scale (DASS21),
post-COVID-19 syndrome symptoms
Diagnostic Test: Body composition
Dual-energy x-ray absorptiometry (DXA)
Inclusion Criteria:
- tested positive for SARS-CoV-2 using antigen- or PCR tests within the last 18 months
- previous hospitalisation due to COVID-19
- fully vaccinated (only for controls)
Exclusion Criteria:
- inability to follow the study procedures (e.g. due to language barriers,
psychological disorders, dementia, etc.),
- known pregnancy or lactating women,
- presence of any contraindications for exercising until maximum exhaustion, including
insufficient blood pressure control (systolic >170 mmHg, diastolic >100 mmHg),
ongoing cancer treatment, unstable angina pectoris, uncontrolled bradyarrhythmia or
tachyarrhythmia, severe uncorrected valvular heart disease, clinically relevant
acute infection, any form of musculoskeletal injury,
- participating in any interventional clinical trial within the last four weeks,
- previous participation in the current study
- history of symptomatic COVID-19 (only for controls)
Division of Sports and Exercise Medicine, Department of Sport, Exercise and Health, University of Basel
Basel, BS, Switzerland
Investigator: Arno Schmidt-Trucksäss, MD, MA, FESC
Contact: + 41 61 377 87 41
arno.schmidt-trucksaess@unibas.ch
Arno Schmidt-Trucksäss, Prof.
+41 61 207 47 40
arno.schmidt-trucksaess@unibas.ch
Arno Schmidt-Trucksäss, Prof., Principal Investigator
Department of Sport, Exercise and Health, University of Basel, Basel, Switzerland