Inclusion Criteria:

A subject must meet all of the following criteria to be eligible to participate in this
study:

1. Provides written informed consent prior to initiation of any study procedures.

2. Be able to understand and agrees to comply with planned study procedures and be
available for all study visits.

3. Agrees to the collection of venous blood per protocol.

4. Male or non-pregnant female, >/= to 18 years of age at time of enrollment.

5. Body Mass Index (BMI) 18.0-35.0 kg/m^2, inclusive (< 56 years of age), at screening;
BMI 18.0-30.0 kg/m^2, inclusive (>/= 56 years of age), at screening.

6. Women of childbearing potential* must agree to use or have practiced true abstinence**
or use at least one acceptable primary form of contraception.***, **** Note: These
criteria are applicable to females in a heterosexual relationship and child-bearing
potential (i.e., the criteria do not apply to subjects in a same sex relationship).

- Not of childbearing potential - post-menopausal females (defined as having a
history of amenorrhea for at least one year) or a documented status as being
surgically sterile (hysterectomy, bilateral oophorectomy, tubal
ligation/salpingectomy, or Essure(R) placement).

- True abstinence is 100% of time no sexual intercourse (male's penis enters
the female's vagina). (Periodic abstinence [e.g., calendar, ovulation,
symptothermal, post-ovulation methods] and withdrawal are not acceptable
methods of contraception).

- Acceptable forms of primary contraception include monogamous
relationship with a vasectomized partner who has been vasectomized for
180 days or more prior to the subject's first vaccination, intrauterine
devices, birth control pills, and injectable/implantable/insertable
hormonal birth control products.

- Must use at least one acceptable primary form of contraception for
at least 30 days prior to the first vaccination and at least one
acceptable primary form of contraception for 60 days after the
last vaccination.

7. Women of childbearing potential must have a negative urine or serum pregnancy test
within 24 hours prior to each vaccination.

8. Male subjects of childbearing potential*: use of condoms to ensure effective
contraception with a female partner of childbearing potential from first vaccination
until 60 days after the last vaccination.

*Biological males who are post-pubertal and considered fertile until permanently
sterile by bilateral orchiectomy or vasectomy.

9. Male subjects agree to refrain from sperm donation from the time of first vaccination
until 60 days after the last vaccination.

10. In good health.* *As determined by medical history and physical examination to
evaluate acute or ongoing chronic medical diagnoses/conditions that have been present
for at least 90 days, which would affect the assessment of safety of subjects. Chronic
medical diagnoses/conditions should be stable for the last 60 days (no
hospitalizations, emergency room (ER), or urgent care for condition or need for
supplemental oxygen). This includes no change in chronic prescription medication,
dose, or frequency as a result of deterioration of the chronic medical
diagnosis/condition in the 60 days before enrollment. Any prescription change that is
due to change of health care provider, insurance company, etc., or done for financial
reasons, and in the same class of medication, will not be considered a deviation of
this inclusion criterion. Any change in prescription medication due to improvement of
a disease outcome, as determined by the participating site principal investigator (PI)
or appropriate sub-investigator, will not be considered a deviation of this inclusion
criterion. Subjects may be on chronic or as needed (prn) medications if, in the
opinion of the participating site PI or appropriate sub-investigator, they pose no
additional risk to subject safety or assessment of reactogenicity and immunogenicity,
and do not indicate a worsening of medical diagnosis/condition. Similarly, medication
changes subsequent to enrollment and study vaccination are acceptable provided the
change was not precipitated by deterioration in the chronic medical condition, and
there is no anticipated additional risk to the subject or interference with the
evaluation of responses to study vaccination.

11. Oral temperature is less than 100.0 degrees Fahrenheit (37.8 degrees Celsius).

12. Pulse no greater than 100 beats per minute.

13. Systolic blood pressure (BP) is 85 to 150 mm Hg, inclusive.

14. Clinical screening laboratory evaluations (white blood cell (WBC), hemoglobin (Hgb),
platelets (PLTs), alanine transaminase (ALT), aspartate transaminase (AST), creatinine
(Cr), alkaline phosphatase (ALP), total bilirubin (T. Bili), Lipase, prothrombin time
(PT), and partial thromboplastin time (PTT)) are within acceptable normal reference
ranges at the clinical laboratory being used.

15. Must agree to have samples stored for secondary research.

16. Agrees to adhere to Lifestyle Considerations throughout study duration.

17. Must agree to refrain from donating blood or plasma during the study (outside of this
study).

Leukapheresis Inclusion Criteria:

A subject must meet all of the following criteria to be eligible for leukapheresis:

1. Written informed consent for leukapheresis is provided.

2. Weight >/= 110 pounds.

3. Screening laboratory evaluations are within acceptable ranges at the site where the
leukapheresis procedure will be performed.

4. Negative urine or serum pregnancy test within 48 hours of the leukapheresis procedure
for women of childbearing potential.

5. Adequate bilateral antecubital venous access.

6. No use of blood thinners, aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) at
least 5 days before the leukapheresis procedure.

7. Enrolled in cohorts 2, 3, 5, 10, or 11, and possibly cohort 6, if enrolled, and
completed the two-dose vaccination series.

Optional Substudy Inclusion Criteria:

1. Enrolled in the main study and received both the first and second mRNA-1273
vaccinations.

2. Provides written informed consent for the third mRNA-1273 vaccination.

3. Agrees to the collection of venous blood per substudy.

4. Must agree to have samples stored for secondary research.

5. Women of childbearing potential have had a negative urine pregnancy test within 24
hours before the third mRNA-1273 vaccination.

6. Women of childbearing potential* must agree to use or have practiced true abstinence**
or use at least one acceptable primary form of contraception.***/****

- Not of childbearing potential - post-menopausal females (defined as having a
history of amenorrhea for at least one year) or a documented status as being
surgically sterile (hysterectomy, bilateral oophorectomy, tubal
ligation/salpingectomy, or Essure® placement).

- True abstinence is 100% of time no sexual intercourse (male's penis enters
the female's vagina). (Periodic abstinence [e.g., calendar, ovulation,
symptothermal, post-ovulation methods] and withdrawal are not acceptable
methods of contraception).

- Acceptable forms of primary contraception include monogamous
relationship with a vasectomized partner who has been vasectomized for
180 days or more prior to the subject's first vaccination, intrauterine
devices, birth control pills, and injectable/implantable/insertable
hormonal birth control products.

****Must use at least one acceptable primary form of contraception for
at least 30 days prior to the third mRNA-1273 vaccination and for at
least 30 days after the third mRNA-1273 vaccination.

Exclusion Criteria:

A subject who meets any of the following criteria will be excluded from participation in
this study:

1. Positive pregnancy test either at screening or just prior to each vaccine
administration.

2. Female subject who is breastfeeding or plans to breastfeed from the time of the first
vaccination through 60 days after the last vaccination.

3. Has any medical disease or condition that, in the opinion of the participating site
principal investigator (PI) or appropriate sub-investigator, precludes study
participation.*

*Including acute, subacute, intermittent or chronic medical disease or condition that
would place the subject at an unacceptable risk of injury, render the subject unable
to meet the requirements of the protocol, or may interfere with the evaluation of
responses or the subject's successful completion of this trial.

4. Presence of self-reported or medically documented significant medical or psychiatric
condition(s).*

*Significant medical or psychiatric conditions include but are not limited to:
Respiratory disease (e.g., chronic obstructive pulmonary disease [COPD], asthma)
requiring daily medications currently or any treatment of respiratory disease
exacerbations (e.g., asthma exacerbation) in the last 5 years. Asthma medications:
inhaled, oral, or intravenous (IV) corticosteroids, leukotriene modifiers, long and
short acting beta agonists, theophylline, ipratropium, biologics.

Significant cardiovascular disease (e.g., congestive heart failure, cardiomyopathy,
ischemic heart disease), history of myocarditis or pericarditis as an adult,
myocardial infarction (MI) within past 6 months, coronary artery bypass surgery or
stent placement, or uncontrolled cardiac arrhythmia.

Neurological or neurodevelopmental conditions (e.g., history of migraines in the past
5 years, epilepsy, stroke, seizures in the last 3 years, encephalopathy, focal
neurologic deficits, Guillain-Barré syndrome, encephalomyelitis, transverse myelitis,
stroke or transient ischemic attack, multiple sclerosis, Parkinson's disease,
amyotrophic lateral sclerosis, Creutzfeldt-Jakob disease, or Alzheimer's disease).

Ongoing malignancy or recent diagnosis of malignancy in the last five years excluding
basal cell and squamous cell carcinoma of the skin, which are allowed.

An autoimmune disease, including hypothyroidism without a defined non-autoimmune
cause, localized or history of psoriasis.

An immunodeficiency of any cause. Chronic kidney disease, estimated glomerular
filtration rate (eGFR) <60 mL/min/1.73m^2.

5. Has an acute illness*, as determined by the participating site PI or appropriate
sub-investigator, with or without fever [oral temperature >/= 38.0 degrees Celsius
(100.4 degrees Fahrenheit)] within 72 hours prior to each vaccination.

*An acute illness which is nearly resolved with only minor residual symptoms remaining
is allowable if, in the opinion of the participating site PI or appropriate
sub-investigator, the residual symptoms will not interfere with the ability to assess
safety parameters as required by the protocol.

6. Has a positive test result for hepatitis B surface antigen, hepatitis C virus
antibody, or human immunodeficiency virus (HIV) types 1 or 2 antibodies at screening.

7. Has participated in another investigational study involving any investigational
product* within 60 days, or 5 half-lives, whichever is longer, before the first
vaccine administration.

*study drug, biologic or device

8. Currently enrolled in or plans to participate in another clinical trial with an
investigational agent* that will be received during the study-reporting period.**

*Including licensed or unlicensed vaccine, drug, biologic, device, blood product, or
medication.

**13 months after the first vaccination.

9. Has previously participated in an investigational study involving lipid nanoparticles
(LNPs) (a component of the investigational vaccine assessed in this trial).

10. Has a history of hypersensitivity or severe allergic reaction (e.g., anaphylaxis,
generalized urticaria, angioedema, other significant reaction) to any previous
licensed or unlicensed vaccines.

11. Chronic use (more than 14 continuous days) of any medications that may be associated
with impaired immune responsiveness.*

*Including, but not limited to, systemic corticosteroids exceeding 10 mg/day of
prednisone equivalent, allergy injections, immunoglobulin, interferon,
immunomodulators, cytotoxic drugs, or other similar or toxic drugs during the
preceding 6-month period prior to vaccine administration (Day 1). The use of low dose
topical, ophthalmic, inhaled and intranasal steroid preparations will be permitted.

12. Anticipating the need for immunosuppressive treatment within the next 6 months.

13. Received immunoglobulins and/or any blood or blood products within the 4 months before
the first vaccine administration or at any time during the study.

14. Has any blood dyscrasias or significant disorder of coagulation.

15. Has any chronic liver disease, including fatty liver.

16. Has a history of alcohol abuse or other recreational drug (excluding cannabis) use
within 6 months before the first vaccine administration.

17. Has a positive test result for drugs of abuse at screening or before the first vaccine
administration. If cannabis is the only detected drug, inclusion is permitted.

18. Has any abnormality or permanent body art (e.g., tattoo) that would interfere with the
ability to observe local reactions at the injection site (deltoid region).

19. Received or plans to receive a licensed, live vaccine within 4 weeks before or after
each vaccination.

20. Received or plans to receive a licensed, inactivated vaccine within 2 weeks before or
after each vaccination.

21. Receipt of any other SARS-CoV-2 or other experimental coronavirus vaccine at any time
prior to or during the study.

22. Close contact of anyone known to have SARS-CoV-2 infection within 30 days prior to
vaccine administration.

23. History of COVID-19 diagnosis.

24. On current treatment with investigational agents for prophylaxis of COVID-19.

25. Current use of any prescription or over-the-counter medications within 7 days prior to
vaccination, unless approved by the investigator or necessary to manage a chronic
condition.

26. Plan to travel outside the United States (US) (continental US, Hawaii, and Alaska)
from enrollment through 28 days after the last vaccination.

27. Reside in a nursing home or other skilled nursing facility or have a requirement for
skilled nursing care.

28. Non-ambulatory.

29. For subjects >/= 56 years of age, history of chronic smoking within the prior year.

30. For subjects >/= 56 years of age, current smoking or vaping.

31. For subjects >/= 56 years of age, individuals currently working with high risk of
exposure to SARS-CoV-2 (e.g., active health care workers with direct patient contact,
emergency response personnel).

Optional Substudy Exclusion Criteria:

1. Anaphylaxis or other systemic hypersensitivity reaction following a mRNA-1273 or any
other vaccination.

2. Immediate allergic reaction of any severity after mRNA-1273 or any of its components.*

*Including polyethylene glycol (PEG)

3. Immediate allergic reaction of any severity to polysorbate.*

*Due to potential cross-reactive hypersensitivity with the vaccine ingredient PEG

4. History of an SAE judged related to mRNA-1273 vaccine.

5. Female subject who is breastfeeding or plans to breastfeed from the time of the third
mRNA-1273 vaccination through 30 days after the third mRNA-1273 vaccination.

6. Has an acute illness*, as determined by the participating site PI or appropriate
sub-investigator, with or without fever [oral temperature >/=38.0°C (100.4°F)], within
72 hours prior to the third mRNA-1273 vaccination.

*An acute illness which is nearly resolved with only minor residual symptoms remaining
is allowable if, in the opinion of the participating site PI or appropriate
sub-investigator, the residual symptoms will not interfere with the ability to assess
safety parameters as required by the substudy.

7. Has received any approved, authorized or investigational COVID-19 vaccine outside of
this trial.

8. Any clinically significant medical condition that, in the opinion of the investigator,
poses an additional risk to the subject from vaccination.

9. History of documented COVID-19 infection.

10. Has any medical disease or condition that, in the opinion of the participating site PI
or appropriate sub-investigator, precludes substudy participation.

11. Received or plans to receive a licensed vaccine, other than a COVID-19 vaccine, within
2 weeks before or after the third mRNA-1273 vaccination.