Inclusion Criteria:

Phase I:

Participants are eligible to be included in the study only if the following conditions
are met:

1. Male or female aged ≥18 years old when signing ICF;

2. Participants that were fully vaccinated with mRNA anti-SARS-CoV-2 vaccine, and the
last dose is ≥6 months away from the vaccination of this study.

3. Participants that can sign written ICF and voluntarily participate in the trial, and
can fully understand the trial procedure, the risk of participating in the trial,
and other interventions that can be selected if they do not participate in the
trial;

4. Ability to read, understand, and fill in record cards;

5. Those who are clinically judged to be healthy, the results of physical examination,
vital signs and laboratory tests during the screening period are normal, or although
beyond the normal reference range, they are judged by investigators to be of no
clinical significance;

6. Fertile men and women of childbearing age voluntarily agree to take effective
contraceptive measures from signing ICF to 6 months after the study vaccination; the
pregnancy test results of women of childbearing age are negative on screening.

Phase II:

Participants are eligible to be included in the study only if the following conditions
are met:

1. Male or female aged ≥18 years old when signing ICF;

2. Participants that were fully vaccinated with mRNA anti-SARS-CoV-2 vaccine, and the
last dose is ≥6 months away from the vaccination of this study.

3. Participants that can sign written ICF and voluntarily participate in the trial, and
can fully understand the trial procedure, the risk of participating in the trial,
and other interventions that can be selected if they do not participate in the
trial;

4. Ability to read, understand, and fill in record cards;

5. Healthy participants or participants with pre-existing medical conditions who are in
stable condition. The "pre-existing medical conditions" include but not limited to
hypertension, diabetes, Chronic cholecystitis and cholelithiasis, chronic gastritis
that meet the described criteria. A stable medical condition is defined as disease
not requiring significant change in therapy or no need for hospitalization as a
consequence of worsening disease state for at least 3 months prior to enrollment;

6. Fertile men and women of childbearing age voluntarily agree to take effective
contraceptive measures from signing ICF to 6 months after the study vaccination; the
pregnancy test results of women of childbearing age are negative on screening.

Exclusion Criteria:

Phase I:

A participant who conforms to any of the following criteria should not be enrolled in the
study:

1. Previous diagnosis of COVID-19;

2. High-risk populations (such as medical workers, close contacts of patients with
COVID-19 infection, etc.) who are more likely to be infected with SARS-Cov-2;

3. Presence of fever within 3 days before the study vaccination;

4. A history of infection or disease related to severe acute respiratory syndrome
(SARS), Middle East respiratory syndrome (MERS), or corresponding
immunosuppressants;

5. A history of allergic reactions to any vaccine or drug, such as allergy, urticaria,
severe skin eczema, dyspnea, laryngeal edema, and angioneurotic edema;

6. A medical or family history of seizure, epilepsy, encephalopathy and psychosis;

7. Immunocompromised patients suffering from immunodeficiency diseases, important organ
diseases, immune diseases (including Guillain-Barre Syndrome [GBS], systemic lupus
erythematosus, rheumatoid arthritis, asplenia or splenectomy caused by any
circumstances, and other immune diseases that may have an impact on immune response
in the investigator's opinion), etc.;

8. Long-term use of immunosuppressant therapy or immunomodulatory drugs for ≥14 days
within the first six months prior to enrollment, or plan to use immunosuppressant
therapy or immunomodulatory drugs within two years after enrollment. Whereas
short-term (≤14 days) use of oral, inhaled and topical steroids are allowed.

9. Patients on antituberculosis therapy;

10. Previously or currently suffering from clinically significant cardiovascular
diseases, or clinically significant disorders related to respiratory system, liver
and kidney, gastrointestinal system, endocrine system, blood and lymphatic system,
metabolic and skeletal systems, or malignancies, that may affect the study
assessment, or cause risks during the study vaccination, or interfere with the data
interpretation as determined by the investigator;

11. Contraindications for intramuscular injection or intravenous blood sampling,
including thrombocytopenia and other blood coagulation disorders;

12. Participants who received any immunoglobulin or blood products in the previous 3
months, or plan to receive similar products during the study;

13. Participants who received other investigational drugs within 1 month before the
study vaccination;

14. Participants who is at the acute state of disease, such as acute onset of chronic
heart failure, acute sore throat, hypertensive encephalopathy, acute pneumonia,
acute renal insufficiency, acute cholecystitis;

15. Participants received other drug used for prevention of COVID-19 (exception for
previous mRNA vaccine the participant received) ;

16. Participants vaccinated with influenza vaccine within 14 days or with other vaccines
within 28 days before the study vaccination;

17. Those who donated blood or had blood loss (≥450 mL) within 3 months before the
vaccination or plan to donate blood during the study period;

18. Those who are pregnant or breast-feeding;

19. Those who plan to donate ovum or sperms during the study period;

20. Those who cannot follow the trial procedures, or cannot cooperate to complete the
study due to planned relocation or long-term outing;

21. Those unsuitable for participating in the clinical trial as determined by the
investigator because of other abnormalities that are likely to confuse the study
results, or non-conformance with the maximal benefits of the participants;

22. Those who are tested positive for hepatitis B virus (HBV), hepatitis C virus (HCV),
syphilis or HIV in terms of serology.

Phase II:

A participant who conforms to any of the following criteria should not be enrolled in the
study:

1. Previous diagnosis of COVID-19;

2. Presence of fever within 3 days before the study vaccination;

3. A history of infection or disease related to severe acute respiratory syndrome
(SARS), Middle East respiratory syndrome (MERS), or corresponding
immunosuppressants;

4. A history of allergic reactions to any vaccine or drug, such as allergy, urticaria,
severe skin eczema, dyspnea, laryngeal edema, and angioneurotic edema;

5. A medical or family history of seizure, epilepsy, encephalopathy and psychosis;

6. Immunocompromised patients suffering from immunodeficiency diseases, important organ
diseases, immune diseases (including Guillain-Barre Syndrome [GBS], systemic lupus
erythematosus, rheumatoid arthritis, asplenia or splenectomy caused by any
circumstances, and other immune diseases that may have an impact on immune response
in the investigator's opinion), etc.;

7. Long-term use of immunosuppressant therapy or immunomodulatory drugs for ≥14 days
within the first six months prior to enrollment, or plan to use immunosuppressant
therapy or immunomodulatory drugs within two years after enrollment. Whereas
short-term (≤14 days) use of oral, inhaled and topical steroids are allowed.

8. Patients on antituberculosis therapy;

9. Presence of severe or uncontrollable cardiovascular diseases, or severe or
uncontrollable disorders related to endocrine system, blood and lymphatic system,
liver and kidney, respiratory system, metabolic and skeletal systems, or
malignancies (except for skin basal cell carcinoma and carcinoma in-situ of cervix)
, such as severe heart failure, severe pulmonary heart disease, unstable angina,
liver failure, or uremia;

10. Contraindications for intramuscular injection or intravenous blood sampling,
including thrombocytopenia and other blood coagulation disorders;

11. Participants who received any immunoglobulin or blood products in the previous 3
months, or plan to receive similar products during the study;

12. Participants who received other investigational drugs within 1 month before the
study vaccination;

13. Participants who is at the acute state of disease, such as acute onset of chronic
heart failure, acute sore throat, hypertensive encephalopathy, acute pneumonia,
acute renal insufficiency, acute cholecystitis;

14. Participants received other drug used for prevention of COVID-19 (exception for
previous mRNA vaccine the participant received) ;

15. Participants vaccinated with influenza vaccine within 14 days or with other vaccines
within 28 days before the study vaccination;

16. Those who donated blood or had blood loss (≥450 mL) within 3 months before the
vaccination or plan to donate blood during the study period;

17. Those who are pregnant or breast-feeding;

18. Those who plan to donate ovum or sperms during the study period;

19. Those who cannot follow the trial procedures, or cannot cooperate to complete the
study due to planned relocation or long-term outing;

20. Those unsuitable for participating in the clinical trial as determined by the
investigator because of other abnormalities that are likely to confuse the study
results, or non-conformance with the maximal benefits of the participants;

21. Those who are tested positive for HIV in terms of serology.