Inclusion Criteria:

1. Written or witnessed informed consent obtained from the participant prior to
performance of any study-specific procedure.

2. Participants, who in the opinion of the investigator, can and will comply with the
requirements of the protocol (e.g., completion of the eDiary and study procedures).

3. Has received 2 doses of primary series and booster dose(s) of an authorized or
licensed mRNA COVID-19 vaccine (only Moderna or Pfizer vaccines) with the last
booster dose administered between at least 6 and 18 months or more prior to
screening and has provided documentation of receiving the vaccination series (e.g.,
vaccination card).

4. Negative for SARS-CoV-2 infection by RT-PCR test at screening within 7 days prior to
study vaccination.

5. Is a male or nonpregnant female of 18 to 49 years, inclusive, at screening.

6. If the participant is a woman of childbearing potential (WOCBP), the participant
agrees to practice true abstinence or use at least 1 highly effective form of
contraception for at least 30 days prior to study vaccination up to 1 month after
study vaccination.

7. Agrees to refrain from blood or plasma donation from screening and up to 6 months
after vaccination.

8. Is healthy or medically stable as determined by investigator judgment based on
medical history, clinical laboratory tests, vital sign measurements, and physical
examination findings.

Exclusion Criteria:

1. Has a new onset, clinically significant, abnormal biochemistry or hematology finding
[defined as greater than or equal to (>=) Grade 1] at screening (participants with
Grade 1 laboratory abnormalities that have been stable for at least 6 months before
enrollment may be included in the study).

2. Has any medical disease or condition that, in the opinion of the investigator,
precludes study participation. This includes any acute, subacute, intermittent, or
chronic medical disease or condition that would place the participant at an
unacceptable risk of injury, render the participant unable to meet the requirements
of the protocol, or may interfere with the evaluation of responses or the
participant's successful completion of the trial.

3. Any confirmed or suspected immunosuppressive or immunodeficient condition, based on
medical history and physical examination (no laboratory testing required).

4. History of myocarditis, pericarditis, second- and third-degree heart block or
idiopathic cardiomyopathy, or presence of any medical condition that increases risk
of myocarditis or pericarditis, including cocaine abuse, cardiomyopathy,
endomyocardial fibrosis, hypereosinophilic syndrome, hypersensitivity myocarditis
eosinophilic granulomatosis with polyangiitis, persistent myocardial viral infection
(e.g., due to enterovirus or adenovirus).

5. Has an acute febrile illness with a temperature >=38.0 degree Celsius (°C) or
>=100.4 degree Fahrenheit (°F) observed by the participant or at the study site
within 72 hours prior to study vaccination. Participants with suspected COVID-19
symptoms should be excluded and referred for medical care.

6. Has a history of hypersensitivity or severe allergic reaction, including
anaphylaxis, generalized urticaria, angioedema, and other significant reactions to
any previous vaccine, or any component of the study vaccine.

7. Has a body mass index greater than (>) 40 Kilograms meter per square (kg/m^2).

8. Has had known close contact with anyone who had a confirmed SARS-CoV-2 infection
within 14 days before study vaccination.

9. Has a history of documented SARS-CoV-2 infection or COVID-19 within 6 months before
the date of screening visit.

10. Has any self-reported or medically documented clinically significant medical or
psychiatric condition. Significant medical conditions include, but are not limited
to, the following:

1. Moderate or severe respiratory disease (e.g., chronic obstructive pulmonary
disease, asthma).

2. Uncontrolled hypertension, defined as an average systolic blood pressure >= 140
millimeters of mercury (mmHg) or an average diastolic blood pressure >= 90
mmHg, based on an average of up to 3 blood pressure measurements.

3. Clinically significant cardiovascular disease (e.g., congestive heart failure,
cardiomyopathy, ischemic heart disease).

4. Neurological or neurodevelopmental conditions (e.g., Down syndrome, dementia,
chronic migraine not controlled by medication, epilepsy, stroke or seizures in
the last 3 years, encephalopathy, focal neurologic deficits, Guillain- Barré
syndrome, encephalomyelitis, or transverse myelitis).

5. Ongoing malignancy or recent diagnosis of malignancy in the last 5 years
(excluding basal cell and squamous cell carcinoma of the skin).

6. Tuberculosis or non-tuberculosis mycobacterial infection.

7. Autoimmune disease, including hypothyroidism without a defined nonautoimmune
cause.

8. Immunodeficiency of any cause, including from solid organ transplant, blood, or
bone marrow transplant, or use of other immune-weakening medicine.

9. Type 1 or 2 diabetes mellitus regardless of disease control.

11. Has any of the following self-reported or medically documented risk factors for
severe COVID-19:

1. Chronic kidney disease

2. Cerebrovascular disease

3. Cystic fibrosis

4. Chronic liver disease

5. Pulmonary fibrosis

12. Has participated or plans to participate in another investigational study involving
any investigational drug or device within 60 days or 5 half-lives, whichever is
longer, before study vaccination and throughout the study.

13. Has received a licensed or authorized non-mRNA COVID-19 vaccine (primary series or
booster dose).

14. Has received or plans to receive any licensed vaccine within 4 weeks before or after
study vaccination. Inactivated vaccines for influenza are permitted during the study
if they are administered at least 14 days before or after study vaccination.

15. Is planning to receive an authorized or licensed COVID-19 booster vaccination for
the duration of the study (for participants who are not covered by local
recommendations to receive booster per current standard of care) OR is planning to
receive an authorized or licensed COVID-19 booster vaccination on or before Day 31
of the study (for participants covered by local recommendations to receive booster).

16. Has received or plans to receive immunoglobulins or any blood or blood products
within 90 days before study vaccination and throughout the study.

17. Reports chronic use (more than 14 continuous days) of any medication that may be
associated with changes in immune function including, but not limited to, systemic
corticosteroids exceeding 20 mg/day of prednisone equivalent, allergy injections,
immunoglobulins, interferons, immunomodulators, cytotoxic drugs, or other similar or
toxic drugs within 6 months of study vaccination. Note: The use of low-dose topical,
ophthalmic, inhaled, intra-articular and intranasal steroid preparations is
permitted.

18. Pregnant or lactating female.

19. Female participant planning to become pregnant or planning to discontinue
contraceptive precautions within 1 month following study vaccination.

20. Participant is an employee or family member of the investigator or study site
personnel.