Inclusion Criteria:

1. Subjects must provide informed consent in accordance with requirements of the study
center's institutional review board (IRB) or eithics committee prior to the initiation
of any protocol-required procedures

2. Subjects must agree to provide all requested demographic information (i.e. gender,
race)

3. Subjects must be able to read and understand English or Spanish

4. Subjects must be over the age of 18 years

5. Subjects must have laboratory-confirmed SARS-CoV-2 infection as determined by
PCR-based commercial or public health assay

6. Subjects must have symptoms that require hospitalization with supplemental oxygen and
/ or non-invasive ventilation as determined by the admitting physician. The maximum
nasal cannula O2 concentration should be determined by the treating clinician and the
limitations of the specific equipment

7. Subjects must be willing and able to comply with study-related procedures/assessments

Exclusion Criteria:

1. Subjects in immediate need of invasive mechanical ventilation or extracorporeal
membrane oxygenation (ECMO)

2. Subjects with an eGFR < 30 mL/min, at the Screening Visit

3. Prisoners or subjects who are involuntarily incarcerated

4. Subjects who are participating in any other investigational clinical trial while
participating in this clinical trial

5. Subjects who are under the age of 18 years

6. Subjects who are pregnant (all potential female enrollees need to have a negative
pregnancy test prior to IP administration)

7. Subjects with multi-organ failure

8. Subjects who have received more than 48 hours of supplemental oxygen prior to
randomization

9. Subjects with prior significant pulmonary disease (e.g., severe COPD/ILD/CHF/IPF) are
excluded

10. Subjects receiving investigational therapies as part of a formal clinical trial for
the treatment of COVID-19. During the course of this study, investigational therapies
that may become "standard of care" to treat COVID-19, but are not part of a clinical
trial, are allowed

11. Subjects who are on long-acting CGRP monoclonal antibodies will be excluded including
Aimovig (erenumab), Emgality (galcanezumab), Ajovy (fremanezumab), and Vyepti
(eptinezumab). Additionally, the investigational oral CGRP receptor antagonist,
atogepant, that is taken daily will also be excluded. Oral CGRP receptor antagonists,
Nurtec ODT (rimegepant) and Ubelvy (ubrogepant) that are typically used PRN
infrequently will not be excluded as long the subject was not taking them on a daily
basis and does not take them during the current study

12. Subjects who are unlikely to survive for more than 48 hours from the Screening Visit

13. Subjects with any of the following abnormal laboratory values at screening: aspartate
AST or ALT greater than 5x ULN or bilirubin greater than 2x ULN

14. Subjects with known active TB, history of incompletely treated TB, suspected or known
extrapulmonary TB

15. Subjects with suspected or known systemic bacterial or fungal infections. However,
empiric antibiotics are permitted.

16. Subjects who have participated in any clinical research study evaluating an IP or
therapy within 3 months and less than 5 half-lives of IP prior to the screening visit

17. Subjects with any physical examination findings and/or history of any illness that, in
the opinion of the study investigator, might confound the results of the study or pose
an additional risk to the subject by their participation in the study