This multi-center, retrospective cohort study aimed to determine which factors areassociated with ongoing pregnancy rates in infertile patients received ART treatmentsduring the current outbreak of COVID-19 infection.Couples who underwentIVF-ET/ICSI-ET/FET due to infertility in the department of Reproductive Medicine from2022-11-23 to 2023-01-07 were included. Patients who were infected with Coronavirus wereobservation groups; the infection status and clinical outcome were tracked. Patients whowere not infected with Coronavirus were control groups.
In this multi-center, retrospective cohort study, we included patients who underwent
IVF-ET/ICSI-ET/FET due to infertility in the department of Reproductive Medicine from
2022-11-23 to 2023-01-07. Patients who were infected with Coronavirus were observation
groups; the infection status and clinical outcome were tracked. Patients who were not
infected with Coronavirus were control groups. We compared different parameters between
two groups. The primary outcome was ongoing pregnancy rate. Basic information about
patients' menstruation, sexual desire, and sexual function were collected from Medical
record system. Other information about patients' vaccination status, symptoms related to
viral infection were collected by telephone follow ups. Susceptibility indicators to
COVID-19 infection including fasting blood glucose, insulin, blood lipids,
alpha-function, renin-angiotensinase, I-aldosterone were obtained . Reproductive function
indices AMH, INHB, sex hormones, follicle retrieval rate, Gn days, total Gn, endometrial
thickness, the incidence of OHSS, semen quality, oocyte maturation rate, fertilization
rate, qualified embryo rate, blastocyst formation rate, and other laboratory indices of
both men and women were also collected . Assisted pregnancy outcome: clinical pregnancy
rate, embryo implantation rate, early abortion rate, ongoing pregnancy rate, and other
clinical indicators were analyzed to determine whether there is deference in clinical
outcomes between two groups.
Other: no intervention
no intervention
Inclusion Criteria:
- Diagnosed with infertility
- Patients with IVF-ET/ICSI-ET/FET from 2022/11/23 to 2023/01/07
Exclusion Criteria:
- Patients with contraindications to pregnancy or assisted reproductive technology
Department for Reproductive Medicine, Jinling Hospital
Nanjing, Jiangsu, China
Department of Reproductive Medicine, Nantong Maternal and Child Health Care Hospital
Nantong, Jiangsu, China
Department of Reproductive Medicine, Xuzhou Maternal and Child Health Care Hospital
Xuzhou, Jiangsu, China
Bing Yao, PHD
025-80864609
yaobing@nju.edu.cn
Li Chen, PHD
025-80864609
872276095@qq.com