Prolonged COVID, also known as post-COVID or Sar-CoV-2 infection with post-acutesequelae, refers to a set of multi-organ symptoms that persist in patients who havesuffered SARS-CoV-2 infection, even after of the acute phase of the disease.Approximately 10% of people experience this set of symptoms after their acute COVID hasresolved. Such symptoms may include respiratory problems, myalgia, extreme fatigue,moodiness, cognitive impairment, and difficulty sleeping.Psychological therapies, such as mindfulness, have already demonstrated theireffectiveness in pathologies of this type, improving mental health and physical function,as well as reinforcing acceptance and reducing symptoms. Specifically, amygdala-insulatraining was originally designed for patients with chronic fatigue syndrome as a methodof reducing chronic over-sensitization and heightened fear response of the amygdala,which may be behind some of the symptoms related to both with this pathology as withfibromyalgia.A lot of research is currently being done on different types of treatments such aspharmaceutical, biological, dietary, homeopathic and rehabilitation for the treatment ofpersistent COVID; however, an effective treatment has not yet been found. Therefore, thisstudy aims to evaluate the impact of a retraining intervention of the amygdala and insulafor the improvement of the quality of life of patients with persistent COVID.