Inclusion Criteria:

1. ≥ 18 years of age at the time of enrollment

2. Previous suspected, probable, or confirmed SARS-CoV-2 infection, as defined by the
Pan American Health Organization*

- Suspected* or probable SARS-CoV-2 infection will only be allowed if it occurred
before May 1, 2021, and will be limited to no more than 10% of the study
population. Otherwise, confirmed cases are required.

Suspected case of SARS-CoV-2 infection - Three options, A through C:

A. A person who meets the clinical OR epidemiological criteria. Clinical criteria:
Acute onset of fever AND cough (influenza-like illness) OR Acute onset of ANY THREE
OR MORE of the following signs or symptoms: fever, cough, general, weakness/fatigue,
headache, myalgia, sore throat, coryza, dyspnea, nausea, diarrhea, anorexia.
Epidemiological criteria: Contact of a probable or confirmed case or linked to a
COVID-19 cluster; or B. Acute respiratory infection with history of fever or
measured fever of ≥ 38°C; and cough; with onset within the last 10 days; and who
requires hospitalization; or C. With no clinical signs or symptoms, NOR meeting
epidemiologic criteria with a positive professional use or self-test SARS-CoV-2
Antigen-Rapid Diagnostic Test.

Probable case of SARS-CoV-2 infection:

A. A patient who meets clinical criteria above AND is a contact of a probable or
confirmed case or is linked to a COVID-19 cluster.

Confirmed case of SARS-CoV-2 infection - Two options, A and B:

A. A person with a positive nucleic acid amplification test, regardless of clinical
criteria OR epidemiological criteria; or B. Meeting clinical criteria AND/OR
epidemiological criteria (See suspected case A above for criteria). With a positive
professional use or self-test SARS- CoV-2 Antigen-Rapid Diagnostic Test.

3. Self-reported limitation to physical activity due to the presence of symptoms such
as fatigue, shortness of breath, and/or PEM following a SARS-CoV-2 infection, that
has persisted for at least 12 weeks and is present at the time of consent.

4. Willing, able, and agree to provide informed consent, complete questionnaires and
outcome assessments, and participate in the study, including assigned intervention
or control and study visits whether remote, hybrid, or in-person.

Exclusion Criteria:

An individual who meets any of the following criteria will be excluded from participation
in this study:

1. Known active acute SARS-CoV-2 infection ≤ 4 weeks prior to the consent.

2. Known prior diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
(ME/CFS), not related to SARS-CoV-2 infection.

3. Current or recent use (within the last 14 days) of a formal program utilizing one or
more of the current study intervention(s) or similar intervention(s) to treat the
underlying condition, unless a washout period is permitted per Appendices.

4. Participation in another interventional clinical trial.

5. Any condition that would make the participant, in the opinion of the investigator,
unsuitable for the study.