This study is a platform protocol designed to be flexible so that it is suitable for a wide range of settings within health care systems and in community settings where it can be integrated into COVID-19 programs and subsequent treatment plans. This protocol is a prospective, multi-center, multi-arm, randomized, controlled platform trial evaluating various interventions for use in the treatment of autonomic dysfunction symptoms, including cardiovascular complications and postural orthostatic tachycardia syndrome (POTS), in Post-Acute Sequelae of SARS-CoV-2 infection (PASC) participants. The interventions tested will include non-pharmacologic care and pharmacologic therapies with study drugs.
The hypothesis is that some of the autonomic dysfunction symptoms are immune-mediated, so
immunotherapy and other applicable therapies will result in improvement in autonomic
symptoms.
Interventions will be added to the platform protocol as appendices. Each appendix will
leverage all elements of the platform protocol, with additional elements described in the
individual appendix.
Drug: IVIG (intravenous immunoglobulin)
Participants will receive IVIG for 9 months (36 weeks) with a follow-up period for an additional 3 months (total study duration for 12 months).
Drug: IVIG Placebo
Normal saline given intravenously will be the control (placebo) product. Blinding IV bag and tubing covers will be used for both IVIG and Placebo.
Participants will receive placebo for 9 months (36 weeks) with a follow-up period for an additional 3 months (total study duration for 12 months).
Behavioral: Coordinated Care
Participants will receive coordinated non-pharmacologic care for a duration of 3 months, concurrent with IVIG administration. Coordinated non-pharmacologic care involves volume expansion through high salt diet, water intake, abdominal binder, exercise/rehabilitation, motivation, education, and assisted care through care coordinator.
Behavioral: Usual Care
Participants will receive usual non-pharmacologic care (control) for a duration of 3 months, concurrent with IVIG administration.
Inclusion Criteria:
- See NCT06305780 for RECOVER-AUTO: Platform Protocol level inclusion criteria which
applies to this appendix (or sub-study)
Additional Appendix A (IVIG Sub-study) Level Inclusion Criteria:
1. Abnormal active standing test defined as presence of orthostatic tachycardia (an
increase of 30 beats per minute (bpm) or more in HR within 10 minutes upon standing
without orthostatic hypotension) and experiencing orthostatic symptoms
2. COMPASS-31 Score > 40
Exclusion Criteria:
- See NCT06305780 for RECOVER-AUTO: Platform Protocol level exclusion criteria which
applies to this appendix (or sub-study)
Additional Appendix A (IVIG Sub-study) Level Exclusion Criteria:
1. Current or previous IVIG treatment
2. Contraindication to intravenous immunoglobulin.
3. Known allergic reactions to blood products including IVIG and/or subcutaneous
immunoglobulin (SCIG), such as history of clinically relevant hemolysis after IVIG
infusion, aseptic meningitis, recurrent severe headache, hypersensitivity, severe
generalized or severe local skin reactions
4. Selective IgA deficiency
5. Current and recent (within 5 half-lives) use of high-dose corticosteroids (for example
for prior solid organ transplant), omalizumab, anti-TNF-alpha inhibitors
6. Use of immunosuppressants such as Plaquenil, or low-dose steroid (prednisone, no more
than 10mg a day) will be excluded unless the participant is on stable (>4 weeks) dose
7. Significant thrombotic events after the acute phase of COVID-19 and/or within 6 months
of enrollment
8. Veins that are not viable for infusions
9. Not willing to adhere to dosing schedule for IVIG infusions for 9 months
All sites listed under NCT06305780
Durham, North Carolina, United States