COVID-19 has a variety of symptoms from asymptomatic respiratory dysfunction to death.Considering the pathophysiology of SARS-CoV-2 and its relationship with the neuroimmunesystem, response, autonomic balance, musculoskeletal and respiratory and neuropsychiatricsymptoms presented by patients, the investigators highlight the potential use ofnon-invasive neuromodulation methods to assess the effectiveness of treating patientswith COVID-19, as these techniques can be useful in the management of important clinicalaspects in the functional recovery of individuals affected by the disease.The investigators intend to evaluate the effects of HD- tDCS to promote ventilatoryweaning in patients admitted to the Intensive Care Unit (ICU) and to improve therespiratory performance of those hospitalized in nursing beds for treatment of COVID -19.
Not Provided
Other: Active HD-tDCS 3mA
This group will receive HD-tDCS 3mA intensitie. 0 sessions at ICU simultaneously to
physical rehabilitation. The HD- tDCS will be started with a 30 s ramp-up to the desired
intensity, which was maintained for 20 min.
Other: Sham HD-tDCS
This group will receive sham HD-tDCS. The intervention will be applied in 10 sessions at
ICU simultaneously to physical rehabilitation. The HD- tDCS will be started with a 30 s
ramp-up them turn off.
Intensive Care Unit's Inclusion Criteria:
Patients of at least 18 years-old with a PCR-confirmed SARS-CoV-2 diagnosis and receiving
mechanical ventilation at least 48 hours of meeting criteria for moderate to severe acute
respiratory distress syndrome (ARDS), under weaning, were enrolled in this study. An ARDS
diagnosis was made according to the Berlin Definition criteria.
Intensive Care Unit's Exclusion Criteria:
Patients were excluded if they had a condition that could prevent adequate performance of
inspiratory muscle training (e.g., neuropathy or myopathy), pregnancy or active
lactation, Richmond Agitation and Sedation Scale (RASS) scores between -2 and + 1,
Glasgow Coma Scale (GCS) ≤ 8, consent refusal, and contraindications to brain stimulation
(e.g., aneurysm clips).
Federal University of Paraíba,Department of Psychology
João Pessoa, Paraíba, Brazil
Investigator: Suellen Andrade
Contact: 986046032
suellenandrade@gmail.com
Investigator: Suellen Andrade
Suellen Andrade, Phd
986046032 - 5583
suellenandrade@gmail.com
Maria Cecilia Silvestre
996381737 - 5584
ceciliasilvestre.to@gmail.com
Not Provided