Recent research evidence shows that levels of antibodies acquierd post vacunation againstSARS-Cov-2 decrease over time as well as the efficacy to control the infection,additionally in a multicenter study carried out in 2020 were evidenced differences in thetime it took to decrease the antibodies according to the type of vaccine, defined as mRNAor other types of vaccine.In this study , the variation of the SARS-Cov-2 antibody levels in patients from Valle deAburrá will be correlated according to the COVID-19 vaccine received.
After being informed about the study, all patients giving written informed consent will
undergo a serial IgM -IgG COVID-19 antibodies blood test and SARS-Cov-2 PCR by
nasopharingeal swab, that will be taken at the beginning of the study and mensually for
two months.
During the study will be done an active search for SARS-CoV-2 infections in the
vaccinated people cohort, and if it is posible to characterize the variant of SARS-CoV-2
in participants previously vaccinated against this pathogen.
The main objective of this study is to describe the pattern of antibodies blood test
based in the type of vaccine and correlated the pattern of antibodies SARS-Cov-2 levels
in a population of Valle de Aburrá.
Diagnostic Test: Levels of IgG and IgM SARS-CoV-2 antibodies blood test.
0,1,2 months
Diagnostic Test: RT-PCR SARS-CoV-2 nasopharyngeal swab
0,1,2 months
Inclusion Criteria:
- Adult over 18 years old
- The vaccinated patients to be included must have received a complete vaccination
scheme for COVID-19 according to the Ministerio de Salud y Protección Social de
Colombia
- SARS-CoV-2 infection in the last 2 months, verified by rtPCR test
Exclusion Criteria:
- Immunocompromised patients
- Immunosuppressive treatments, chemotherapy or antiretroviral therapy
- Outpatient anticoagulant therapy
- For vaccinated people (groups 1 and 2): if have had COVID-19 infection in the last 6
months
Laboratorio Integrado de Medicina Especializada
Medellin, Antioquia, Colombia
Investigator: Andres F Zuluaga
Ivone Jimenez
+57 (4) 2196022
ivone.jimenez@udea.edu.co
Andres F Zuluaga, MD, MSc, MeH, Principal Investigator
Universidad de Antioquia