The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerginginfectious disease with high transmissibility. Around 20-25% of infected individualsdevelop severe COVID-19 disease requiring hospitalization and 5-8% require intubationsecondary to viral pneumonia and acute respiratory distress syndrome (ARDS). Distinctfeatures of COVID-19 ARDS were found since Nov 2019, including relatively normal lungmechanics, activation of the RAAS system, selective injury of type II alveolar cells, andpresence of vasodilation vessel and micro-thrombosis. The mechanism, potential usefulbiomarker, and the optimal ventilation strategies for COVID-19 ARDS need to besystematically studied. This study hypothesized that the low-tidal volume ventilationstrategy is effective in COVID-19 ARDS. We will retrospectively review the clinicalpresentation, epidemiologic data, laboratory and image examination, medication use, lungmechanics、serum biomarker, long-term pulmonary function test, and clinical outcomes inCOVID-19 ARDS, influenza ARDS, and SARS ARDS patients. We will also prospectively monitorthe lung function of COVID ARDS patients using personal pulmonary function devices afterdischarge from NTUH. The overall purpose of this study is to investigate the prognosticindicators of COVID ARDS patients and their long-term pulmonary function follow-up.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging
infectious disease with high transmissibility. Around 20-25% of infected individuals
develop severe COVID-19 disease requiring hospitalization and 5-8% require intubation
secondary to viral pneumonia and acute respiratory distress syndrome (ARDS). Distinct
features of COVID-19 ARDS were found since Nov 2019, including relatively normal lung
mechanics, activation of the RAAS system, selective injury of type II alveolar cells, and
presence of vasodilation vessel and micro-thrombosis. The mechanism, potential useful
biomarker, and the optimal ventilation strategies for COVID-19 ARDS need to be
systematically studied. This study hypothesized that the low-tidal volume ventilation
strategy is effective in COVID-19 ARDS. We will retrospectively review the clinical
presentation, epidemiologic data, laboratory and image examination, medication use, lung
mechanics、serum biomarker, long-term pulmonary function test, and clinical outcomes in
COVID-19 ARDS, influenza ARDS, and SARS ARDS patients. We will also prospectively monitor
the lung function of COVID ARDS patients using personal pulmonary function devices after
discharge from NTUH. The overall purpose of this study is to investigate the prognostic
indicators of COVID ARDS patients and their long-term pulmonary function follow-up.The
SARS-CoV-2 (COVID-19) ARDS is an emerging novel devastating disease with high mortality.
Distinct features were found since Nov 2019, including relatively normal lung mechanics,
activation of the RAAS system, selective injury of type II alveolar cells, and presence
of vasodilation vessel and micro-thrombosis. The optimal ventilation strategies for
COVID-19 ARDS need to be systematically studied. The overall purpose of this study is to
investigate the prognostic indicators in COVID-19 ARDS patients.Specific Aim 1: To
develop a REDcap database of clinical and biologic information in subjects with COVID-19,
and to investigate the prognostic indicators compared with influenza and SARS ARDS
patients.Specific Aim 2: To follow up the long-term change pulmonary function test of
COVID ARDS patients using home-based personal pulmonary function test device
Inclusion Criteria:
1. Adult >20 years old
2. Retrospective cohort by medical chart review：COVID-19 patients, Influenza patients,
and SARS patients at NTUH
3. Prospective cohort：COVID-19 confirmed patients intubated and receiving mechanical
ventilation > 24 hours at NTUH, got extubated and discharged
Exclusion Criteria:
1. Pregnancy
2. No consent/inability to obtain consent or appropriate legal representative not
available
National Taiwan University Hospital
Taipei, Taiwan
Chin-Chung Shu, Principal Investigator
National Taiwan University Hospital