Official Title
PURE-LC - Probiotic Use for Recovery Enhancement From Long COVID
Brief Summary

The goal of this clinical trial is to learn if probiotics can improve symptoms andquality of life in participants with Long COVID.

Detailed Description

The goal of this clinical trial is to learn if probiotics can improve symptoms and
quality of life in participants with Long COVID. The main questions it aims to answer
are:

1. Do probiotics reduce the number and severity of symptoms in those with Long COVID?

2. Do probiotics improve the physical and mental health quality of life in those with
Long COVID?

3. Do probiotics improve return to work and daily activities in those with Long COVID?

Researchers will compare probiotics to a placebo (a look-alike substance that contains no
probiotics) to see if probiotics work to treat Long COVID.

Participants will take the study medication (placebo or probiotic) for 4 months. They
will then cross over (take the other medication) for an additional 4 months. Participants
will complete a survey at baseline, 4 months, and 8 months.

Active, not recruiting
Post-acute COVID-19 Syndrome

Drug: Probiotic Agent

BlueBiology: Ultimate Care probiotic pill taken once daily for a four-month period.
Other Name: BlueBiotics: Ultimate Care

Other: Placebo

Placebo produced to be identical in taste and appearance to the probiotic agent, taken
once daily for a four-month period.

Eligibility Criteria

Inclusion Criteria:

- Age ≥18 years who report Long COVID with persistent symptoms at the time of study
initiation

Exclusion Criteria:

- No longer have symptoms consistent with LC

- Are unable to take the study medication daily

- Are currently pregnant or planning to become pregnant over the course of the study

- Are currently breastfeeding

- Have been diagnosed with an immune-compromising condition

- Are currently taking immunosuppressants

- Do not speak English as a primary language

- Are regularly taking probiotics

- Are enrolled in another Long COVID study with an intervention

Eligibility Gender
All
Eligibility Age
Minimum: 18 Years ~ Maximum: N/A
Countries
United States
Locations

Rush University Medical Center
Chicago 4887398, Illinois 4896861, United States

Not Provided

Rush University Medical Center
NCT Number
Keywords
long COVID
Post-Acute Sequelae of COVID
MeSH Terms
Post-Acute COVID-19 Syndrome
Counterfeit Drugs