Healthcare workers (HCW) at risk of Covid-19 will have baseline serology for SARS-CoV-2 to see if they are already immune to Covid-19. HCW will get baseline assessment and if meeting inclusion criteria and no exclusion criteria they will be randomized in a 2:1 ratio to hydroxychloroquine or Vitamin C on a weekly basis for three months. Subjects will complete daily diary of symptoms and temperature, and will have repeat SARS-CoV-2 serology at 6 weeks and 3 months to determine seroconversion.
Healthcare workers (HCW) at risk of Covid-19 will have baseline serology for SARS-CoV-2 to
see if they are already immune to Covid-19. HCW will get baseline assessment and if meeting
inclusion criteria and no exclusion criteria they will be randomized in a 2:1 ratio to
hydroxychloroquine or Vitamin C on a weekly basis for three months. Subjects will complete
daily diary of symptoms and temperature, and will have repeat SARS-CoV-2 serology at 6 weeks
and 3 months to determine seroconversion.
Drug: Hydroxychloroquine
Oral loading dose followed by once weekly dosing
Other: Vitamin C
Once daily vitamin C 1 gm
Inclusion Criteria:
- Healthcare worker at risk of Covid-19
Exclusion Criteria:
- Known hypersensitivity or allergic reactions to 4-aminoquinoline compounds or its
ingredients.
- Current, or history of, ocular macular disease or retinal damage.
- Current, or history of, subnormal glomerular filtration.
- Current use of tamoxifen citrate.
- Current, or history of, cardiomyopathy, atrial, nodal, or ventricular arrhythmias,
torsades de pointes, conduction disorders (bundle branch block/atrio-ventricular heart
block) or biventricular hypertrophy.
- Subjects taking other drugs that have the potential to prolong QT interval if taken
with HCQ.