This study is expected to provide, for the first time, data on Cov2-SARS circulation in asymptomatic children and children with moderate respiratory symptoms in order to construct the severity pyramid of this novel pathogen. This information will be essential in the coming weeks to understand the dynamics of the transmission of this pathogen at the population level and to highlight the relevance of public health interventions, particularly with regard to the systematic closure of schools and childcare facilities.
Cov2-SARS is an emerging respiratory virus of the coronavirus family responsible for a global
epidemic since November 2019. As of March 10, 2020, it had caused more than 160,000 cases of
corona virus disease (COVID-19), including more than 6,500 deaths worldwide. France is one of
the main epidemic outbreaks with more than 5,000 confirmed cases and the number of diagnosed
patients is increasing every day.
The number of confirmed paediatric cases is relatively low, and the mortality rate in
children is close to zero. This contrast suggests that children are more likely to present
pauci-symptomatic or even asymptomatic forms of the disease, which are therefore undiagnosed
in most cases. Given the rapid spread of this virus, and the fact that indigenous cases
without an obvious chain of transmission now appear to be frequent in France, it is possible
that the pauci-symptomatic or asymptomatic child may play a role in the transmission of the
pathogen and the dynamics of the epidemic, as documented for other respiratory pathogens such
as influenza. Based on this hypothesis, the closure of children's communities has been
organized in France and other highly endemic countries.
Diagnostic Test: Data collection and rhinopharyngeal swab
Testing for SARS -Cov2 and other respiratory pathogens by PCR via nasopharyngeal swabbing and IgM/IgG rapid serology
Other Name: IgM/IgG rapid serology
Inclusion Criteria:
- Asymptomatic children:
- Age between birth and 15 years
- Carrying out a visit within the framework defined by the learned societies and
professional organisations representative of paediatrics in France, i.e. :
- The consultation of the first month and all consultations involving compulsory
vaccinations (2, 4, 5, 11, 12, 16 months).
- Consultations for acute pathologies, infectious or not.
- Monitoring of chronic diseases that warrant clinical examination (the majority of
which can be carried out by telemedicine) or in the case of acute exacerbation.
- In one of the participating outpatient centres
- During the study period
- With a clinical examination that does not reveal any progressive infectious pathology
AND Pauci-symptomatic children
- Age between birth and 15 years,
- Consultant at one of the participating outpatient centres
- During the study period
- And presenting with a mild respiratory infection:
- Rhinopharyngitis, Acute otitis media, Angina, Bronchitis, etc.
- Acceptance to participate in the protocol by one of the holders of parental authority
- Affiliated to a social security
Exclusion Criteria:
- Refusal to participate in the study
Cabinet du Dr Belaroussi
Boulogne, France
Cabinet du Dr Derkx
Champigny-sur-Marne, France
Cabinet du Dr Coicadan
Chennevières-sur-Marne, France
14 Av rené Samuel
Clamart, France
Cabinet du Dr Corrard
Combs-la-Ville, France
10 rue Delambre
Lagny-sur-Marne, France
157 Avenue du Général Leclerc
Maisons-Alfort, France
21 Grande Rue Charles de Gaulle
Nogent-sur-Marne, France
Cabinet du Dr Deberdt
Nogent-sur-Marne, France
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Nogent-sur-Marne, France
4 allée des Norottes
Noisy-le-Grand, France
Cabinet du Dr D'acremont
Paris, France
146 Avenue Ledru Rollin
Paris, France
132 Boulevard du Montparnasse
Paris, France
Cabinet du Dr Romain
Paris, France
Cabinet du Dr Turberg-Romain
Paris, France
15 Quai Louis Blériot
Paris, France
Cabinet du Dr Michot
Paris, France
24 rue Volta
Puteaux, France
Cabinet du Dr Cohen
Saint-Maur-des-Fossés, France
Cabinet de Pédiatrie des Docteurs Ravilly et Bessa
Villejuif, France
13 Villa Beauséjour
Vincennes, France