The treatment of Methicillin-sensitive Staphylococcus aureus bacteremia is based on thefirst-line use of cefazolin or M penicillins (oxacillin and cloxacillin). The use of thelatter is recommended at high doses (150-200 mg/kg/24h). In a study on infectiousendocarditis, 52 of 56 patients with staphylococcal endocarditis treated with(cl)oxacillin were overdosed with the recommended doses. Although the main mechanism ofrenal toxicity described for M penicillins is immunoallergic, a frequent overdose isobserved in cases of acute renal failure with M penicillins. There is also a significantassociation between overdose and risk of neurological toxicity. The currently recommendedtreatment duration is a minimum of 14 days of IV treatment from the first negative bloodculture, which leaves room for carrying out a plasma assay and possible dosage adjustmentsubsequently.Overdose is a risk factor for nephrotoxicity and neurotoxicity. Plasma level could bepredictive of clinical success. Systematic plasma dosing would reduce the risk oftoxicity and improve the clinical cure rate.
Not Provided
Inclusion Criteria:
- Adult patient (≥18 years old)
- Having presented an infection with Staphylococcus aureus and treated at the
University Hospitals of Strasbourg between January 1, 2019 and December 31, 2022.
Exclusion Criteria:
- Patient having expressed his opposition to the reuse of his data for scientific
research purposes.
Service des Maladies Infectieuses et Tropicales - CHU de Strasbourg - France
Strasbourg 2973783, France
Investigator: Baptiste HOELLINGER, MD
Contact: 33 3 69 55 05 45
baptiste.hoellinger@chru-strasbourg.fr
Baptiste HOELLINGER, MD
33 3 69 55 05 45
baptiste.hoellinger@chru-strasbourg.fr
Not Provided