Inclusion Criteria:

1. Subject is able to read the written informed consent, states willingness to comply
with all study procedures, and is anticipated to be available for all study visits.

2. Male or female adults between 18 and 65 years of age, inclusive.

3. Female participants must either be postmenopausal*, permanently sterile**, or of
childbearing potential with acceptable birth control methods***.

*Postmenopausal: a postmenopausal state is defined as no menses for at least 12
months without an alternative medical explanation, confirmed by a high
follicle-stimulating hormone (FSH) level in the postmenopausal range at screening.
NOTE: If there is a question about menopausal status in women on hormone replacement
therapy (HRT), the woman will be required to use one of the protocol-defined
non-estrogen-containing hormonal highly effective contraceptive methods if she
wishes to continue HRT during the study.

**Permanently sterile: methods include hysterectomy, bilateral salpingectomy,
bilateral oophorectomy, bilateral tubal ligation, or bilateral tubal occlusion.

***Women of childbearing potential (WOCBP): are only eligible if they and any
non-sterile, male sexual partners agree to use protocol-defined highly effective
(dependent or independent) contraceptive therapy, from the start of dosing until at
least 90 days after the last dose. Acceptable method of contraception, including
abstinence from heterosexual intercourse, hormonal contraceptives (e.g., oral,
injectable, implantable, insertable, and transdermal patch), intrauterine device
(with or without hormones), or double-barrier method (e.g., condom and spermicide)
for 30 days prior to Screening, during the study, and for 90 days following the last
administration of investigational product (IP)

4. Male participants must agree to wear a condom with spermicide during sexual
intercourse.* *These contraceptive measures must be implemented, at a minimum, from
the start of dosing until at least 90 days after the last dose. Agreement to remain
abstinent from heterosexual intercourse at the time of Screening, during the study,
and for 90 days following the last administration of IP will be allowed. Male
volunteers must agree not to donate sperm during the study and for 90 days following
the last administration of IP.

5. Participants must have a body mass index (BMI) of 18.0 to 32.0 kg/m^2, extremes
included.

6. Participants must be nonsmokers for at least 3 months prior to
randomization/enrollment.

7. Participants must have a 12-lead electrocardiogram (ECG) that considered in an
acceptable range for inclusion.*

*Criteria includes: heart rate between 40 and 100 beats per minute [bpm], extremes
included; QT interval corrected for heart rate (QTc) according to Fridericia's
formula (QTcF) PR interval >/=110 to criteria, ECG morphology must have no clinically significant abnormalities observed.

NOTE: Retesting of an apparently exclusionary ECG will be allowed once without prior
approval from the Sponsor. Subjects with a retest ECG without clinically significant
abnormalities as per this inclusion criterion may be included.

8. Participants must be deemed to be in good overall health by the Investigator on the
basis of a medical evaluation* performed at Screening.

*Medical evaluation that includes the absence of any clinically significant
abnormality and includes a physical examination, medical history, vital signs, and
the results of blood chemistry, blood coagulation and hematology tests, and a
urinalysis.

9. Subject must be willing and able to adhere to the Prohibited Medication requirements
and Special Precautions as specified in the protocol.

Exclusion Criteria:

1. Participants with any current or previous illness that, in the opinion of the
Investigator, might confound the results of the study or pose risk in administering
study drug to the subject.* *Additionally illnesses that could prevent, limit, or
confound the protocol specified assessments or study results' interpretation. This
may include, but is not limited to, renal, cardiac, vascular, pulmonary,
gastrointestinal, hepatologic, endocrine, neurologic, dermatologic, hematologic,
rheumatologic, psychiatric, neoplastic, or metabolic disturbances.

2. Participants with a past history of cardiac arrhythmias, risk factors for Torsade de
Pointes syndrome or clinical evidence at screening of significant or unstable
cardiac disease.*

*Risk factors for Torsade de Pointes syndrome include hypokalemia and family history
of long QT syndrome. Clinical evidence of cardiac disease include angina, congestive
heart failure, myocardial infarction, diastolic dysfunction, significant arrhythmia,
coronary heart disease, clinically significant ECG abnormalities, moderate to severe
valvular disease or uncontrolled hypertension. Evidence of heart block or bundle
branch block, inclusive of first-degree AV block and incomplete bundle branch block,
on ECG is also exclusionary.

3. Participants with a history of clinically significant drug allergy such as, but not
limited to, sulfonamides or drug allergy witnessed in previous studies with
experimental drugs.

4. Participants with a recent (within 1 year of randomization/enrollment) history of
use of amphetamines, barbiturates, narcotic or other drugs of abuse/recreational
drug use.*

*Use of these drugs under physician supervision (e.g., prescription narcotics for
known pain disorder) are not exclusionary. Cannabis use is also not exclusionary
unless detected at screening or Day -1 (Exclusion Criteria 7).

5. Excessive use of alcohol defined as regular consumption of >/=14 standard
drinks/week .*

*For current definition of a standard drink, refer to the National Institute on
Alcohol Abuse and Alcoholism website.

6. Unwilling to abstain from alcohol use for 1 week prior to start of study through end
of study follow up.

7. Positive results for urine drug screen for barbiturates, opiates, or amphetamines,
alcohol or cotinine test at screening and Day -1.

8. Participants with current viral infections.*

*Viral infections include the following:

- Hepatitis A virus infection (confirmed by hepatitis A antibody immunoglobulin M
[IgM]).

- Hepatitis B infection defined as presence of HBsAg or HBV core antibody.

- Hepatitis C virus (HCV) infection (confirmed by HCV antibody and/or HCV RNA).
Participants who have been treated and achieved sustained virologic response
>/=6 months prior to screening with HCV RNA < Lower limit of quantitation
(LLOQ), target not detected, remain eligible.

- Hepatitis E virus: Anti-HEV IgM-positive and/or detectable HEV RNA level (only
applies to participants with history of living or traveling to an HEV epidemic
area within 90 days of screening).

- Human immunodeficiency virus type 1 (HIV-1) or HIV-2 infection (confirmed by
antibodies) at screening.

- Acute infection at the time of randomization/enrollment. If an acute infection
is considered resolved prior to randomization/enrollment, the subject remains
eligible.

9. Male participants who plan to father a child while enrolled in this study or within
90 days after the last dose of study drug.

10. Women who are breastfeeding or planning to breastfeed throughout the duration of the
study.

11. Use of any medications (prescription and Over-the-counter (OTC)), vitamins, and/or
herbal supplements* within 1 week (or 5 half-lives, whichever is longer) prior to
the first dose of study drug.

*Exception of contraceptives and OTC doses of ibuprofen or acetaminophen of up to 3
doses per week

12. Use of prohibited medications within 14 days (or 5 half-lives, whichever is longer)
prior to the first dose of study drug.

13. Consumption of grapefruit, grapefruit juice, and Seville oranges within 7 days prior
to first study drug administration.

14. Consumption of apple or orange juice, citrus fruits, vegetables from the mustard
green family*, and charbroiled meats within 7 days prior to first study drug
administration.

*Examples are kale, broccoli, watercress, collard greens, kohlrabi, Brussels
sprouts, and mustard.

15. Consumption of any food or drink/beverage containing quinine (e.g., tonic, bitter
lemon, bitter alcoholic beverages containing quinine) within 24 hours prior to study
drug administration.

16. Participants having received an investigational agent within 30 days (or 5
half-lives, whichever is longer) prior to screening.

17. Participants currently participating in another clinical or medical interventional
research study.

18. Participants with any >/=Grade 1 laboratory result that is considered clinically
significant by the Investigator at screening. (Grade 1 laboratory result that is not
clinically significant is allowed.)

19. Clinically significant abnormal vital signs* (evaluated in the supine position after
at least 5 minutes of rest), confirmed with retesting after at least 5 minutes of
additional rest.

*Abnormal vital signs are based on the following criteria:

- Systolic blood pressure: <90 or >145 mmHg

- Diastolic blood pressure: <50 or >95 mmHg

- Pulse rate: <45 or >100 beats per minute

- Temperature: <97 or >99 degrees Fahrenheit

20. Physical examination findings that are considered clinically significant per study
principal investigator and/or study physician and likely to adversely impact study
conduct and/or interpretation are exclusionary.

21. Participants who had major surgery (e.g., requiring general anesthesia) within 12
weeks before screening, planned during the study, or within 4 weeks after the last
dose of study drug.*

*This includes participants who will not have fully recovered from surgery by the
time the participant is expected to participate in the study. NOTE: Participants
with planned surgical procedures to be conducted under local anesthesia may
participate.

22. Participants with renal dysfunction*

*Includes estimated creatinine clearance <80 mL/min/1.73 m^2 at screening or Day -1,
calculated by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)
formula. CKD-EPI should not be corrected for participants of African ancestry.

23. Participants with alanine aminotransferase (ALT) values >1.2× upper limit of normal
(ULN) at screening or Day -1.

24. Participants who donated blood or plasma recently*

*Recently defined as within 56 days prior to screening, or loss of whole blood of
more than 500 mL within 30 days prior to Day-1, or receipt of a blood transfusion
within 1 year of study enrollment; Plasma 7 days prior to screening.

25. Subject is an employee of the Sponsor, the Investigator or study site, with direct
involvement in the proposed study or other studies under the direction of that
Investigator or study site.* *This extends to family members of the employees or the
Investigator