This study aims to assess the effects of both acute and chronic exposures to hypoxia andhypercapnia in patients with Long COVID syndrome.
Not Provided
Other: Acute Placebo Visit
The placebo visit will include 6 simulated cycles of 5 minutes breathing 21% oxygen from
a douglas bag and 5 minutes breathing room air.
Other: Acute Progressive Carbon Dioxide
The progressive carbon dioxide visit will include a 60-minute progressive ramp which
includes 6 cycles of progressive CO2 ramping starting at 0% and progressing up to 10%
within 5 minutes immediately followed with 5 minutes of room air breathing in between
cycles.
Other: Acute Intermittent Hypoxia
The intermittent hypoxia exposure visit will include 6 cycles breathing 8-12% oxygen (O2)
for 5 minutes with a target pulse oximeter saturation of 86-90%, followed by 5 minutes of
breathing room air.
Other: Training: Progressive Carbon Dioxide Ramping
Intervention will consist of 6 to 10 study visits (3-5 sessions/week) to be completed
within 14 days. Subjects will will be given the progressive CO2 ramp protocol of
60-minute sessions, which will include 6 cycles of progressive CO2 ramping starting at 0%
and progressing up to 10% within 5 minutes immediately followed with 5 minutes of room
air breathing in between cycles, for every visit during the 14 days.
Other: Training: Intermittent Hypoxic Exposure
Intervention will consist of 6 to 10 study visits (3-5 sessions/week) to be completed
within 14 days. Subjects will will be given the intermittent hypoxia exposure protocol of
60-minute sessions, which will include 6 cycles breathing 8-12% oxygen (O2) for 5 minutes
with a target pulse oximeter saturation of 86-90%, followed by 5 minutes of breathing
room air for every visit during the 14 days.
Other: Training: Placebo Control
Intervention will consist of 6 to 10 study visits (3-5 sessions/week) to be completed
within 14 days. Subjects will complete 6 simulated cycles of 5 minutes breathing 21%
oxygen from a douglas bag and 5 minutes breathing room air (60 minutes) for every visit
during the 14 days.
Inclusion criteria:
- English speaking
- Diagnosis of Long COVID
Exclusion criteria:
- Any history of:
- Coronary artery dissection or aortic dissection
- Neurological disease (e.g. dementia, Alzheimer's disease, or other
brain-related disease)
- Cerebrovascular disease or stroke
- Aneurysm
- If currently has:
- Moderate-severe chronic obstructive pulmonary disease
- Uncontrolled moderate-severe asthma
- Moderate-severe bronchiectasis
- Moderate-severe interstitial lung disease, requiring the use of supplemental
oxygen
- A necessity to use supplemental oxygen, for any reason
- New or worsening symptoms (decompensation) of heart failure
- Right heart disease due to chronic pulmonary disease/sleep apnea
- Uncontrolled myocardial ischemia or angina
- Uncontrolled heart arrhythmias
- Heart or lung infection (e.g. myocarditis or pericarditis)
- Left main coronary artery stenosis
- Moderate-severe aortic stenosis
- Pulmonary embolism, pulmonary infarction, or other blood clots
- Severe respiratory disease
- Chronic kidney disease
- Chronic liver disease
- Females of childbearing potential will complete a urine pregnancy test at their
baseline visit to rule out pregnancy
- BMI >40
- Study staff unable to obtain adequate signal for cerebral blood flow
Mayo Clinic in Arizona
Scottsdale, Arizona, United States
Investigator: Jordan Parks
Contact: 480-301-6616
parks.jordan@mayo.edu
Investigator: Courtney M Wheatley-Guy, PhD
Jordan Parks
480-301-6616
parks.jordan@mayo.edu
Courtney Wheatley-Guy, Principal Investigator
Mayo Clinic