Official Title
Motivated Decision-Making and Performance
Brief Summary

This proposal aims to understand the neurobiological mechanisms of fatigue in individualswith Post-Acute Sequelae of SARS-CoV-2 Infection (PASC). This knowledge will eventuallyprovide candidate mechanisms to target with pharmacological intervention and informrehabilitative care for those individuals suffering from symptoms of fatigue in PASC.

Detailed Description

Not Provided

Recruiting
PASC Post Acute Sequelae of COVID 19
Fatigue

Behavioral: Physical Fatigue

Participants will perform a physically demanding task (grip force exertion task)
repeatedly to induce physical fatigue.

Eligibility Criteria

Inclusion Criteria:

- Age 18 to 75 years old.

- Have received a clinical diagnosis of post-acute sequelae of SARS-CoV-2 (PASC)/long
COVID syndrome using the criteria specified by Thaweethai, et al., 2023 (JAMA). This
symptom checklist provides a score based on the number and severity of symptoms. An
individual with a score >12 is classified as having PASC.

- Currently experiencing Fatigue/Brain Fog as assessed with the Post-COVID symptom
checklist and the PedsQL questionnaire.

Exclusion Criteria:

- Neurological disorders including, but not limited to, stroke, head injury, epilepsy,
seizures, brain tumors, brain surgery, Parkinson's Disease, or any other
neuromuscular disease (self-report).

- Diagnosed history of severe psychiatric diseases such as depression and
schizophrenia (self-report).

- Congestive heart failure.

- Peripheral artery disease with claudication.

- Cancer.

- Pulmonary or renal failure.

- Unstable angina.

- Uncontrolled hypertension (more than 190/110 mmHg).

- Severe aphasia.

- Orthopedic or pain conditions.

- Have had exposure to metal or metal implants, due to the hazardous effects of the
magnetic field.

- If on immunomodulatory therapy, they must have been on that therapy for at least 6
months before the start of the study.

Healthy age- and sex-matched controls for PASC - Exclusion criteria: Participants with a
history of any of the following will be excluded from the study:

- Hospitalization due to SARS-CoV-2 infection.

- Neurological disorders including, but not limited to, stroke, head injury, epilepsy,
seizures, brain tumors, brain surgery, Parkinson's Disease, or any other
neuromuscular disease (self-report).

- Diagnosed history of severe psychiatric diseases such as depression and
schizophrenia (self-report).

- Congestive heart failure.

- Peripheral artery disease with claudication.

Eligibility Gender
All
Eligibility Age
Minimum: 18 Years ~ Maximum: 75 Years
Countries
United States
Locations

Kennedy Krieger Institute
Baltimore, Maryland, United States

Investigator: Anthony Gonzalez
Contact: 443-923-2716
gonzalezan@kennedykrieger.org

Contacts

Anthony Gonzalez
443-923-2716
gonzalezan@kennedykrieger.org

Vikram Chib, PhD

Vikram Chib, PhD, Principal Investigator
Johns Hopkins University; Kennedy Krieger Institute

National Institute of Neurological Disorders and Stroke (NINDS)
NCT Number
MeSH Terms
Post-Acute COVID-19 Syndrome
Fatigue