The goal of this interventional study is to learn about the improvement in bodycomposition effects of lifestyle intervention in subjects with metabolic syndrome. Themain question it aims to answer is:Does life style intervention lower body fat% and gene methylation levels in subjects withmetabolic syndrome? Participants will answer survey questions and get blood and bodycomposition testing done at day 0, at 6 months and 12 months. Keep a diary of their foodand activity and the number of times they use mobile health application.
This is same as above.
Other: mobile health lifestyle intervention
You will be asked to record all dietary and physical activity log for 12 months on an
application. Mobile sms reminders will be sent to you on regular basis. At day 0, at 6th
and 12 months you will be asked to provide 3 ml of blood for the methylation and advance
glycation level testing and your weight and body fat percentage will be measured. During
this period you will have to follow the lifestyle and diet chart provided to you by the
researchers.
Inclusion Criteria:
1. Less than 5 kg body weight fluctuation in the 6 months prior to recruitment.
2. Ideal body weight for height falling according to the South Asian Criteria as per
WHO recommended i.e. Body Mass Index (BMI) of 18.5 to 22.9 kg/m2 (normal-weight) and
above 23kg/m2 (overweight/ obese).
3. Any one of the following characteristics "according to the modified National
Cholesterol Education Program (NCEP) ATPIII guidelines i) waist circumference ii)
hyper triglyceridemia (triglycerides ≥150 mg/dl) or low High density lipoprotein
(HDL) cholesterol (HDL cholesterol ≤40 mg/dl for men and ≤50 mg/dl for women iii)
elevated blood pressure (systolic blood pressure ≥130 mmHg and/or diastolic blood
pressure ≥85 mmHg or current use of antihypertensive drugs) iv) impaired fasting
glucose (fasting plasma glucose ≥100mg/dl) v) waist circumference (90 cm in men and
80 cm in women)".
4. Have access to a smart phone/mobile and not using the fitness application
Exclusion Criteria:
1. Age <18 or above 65 year
2. Pregnant women
3. Individuals with other comorbidities such as cancers, hepatic and/or renal
impairment, or on hormonal supplements and/or anti-inflammatory drugs etc.
4. Unfit for blood testing or no smart phone available
DBBS
Karachi, Sind, Pakistan
Investigator: Sabah Research Coordinator, MPhil
Contact: +9234864492
Sadia Fatima, PhD
+9234864147
sadia.fatima@aku.edu
Sadia Fatima, PhD, Principal Investigator
Aga Khan University