Mitochondria are structures inside cells that are responsible for producing energy fromnutrients through a series of steps, using oxygen. To have an idea of how well themitochondria can produce energy, we can measure how much oxygen they use. The goal ofthis study is to: 1. To compare the oxygen use between people with long COVID and people who completely recovered after COVID-19, using three techniques that measure the oxygen use in blood cells, on the skin and in the muscle 2. To test how similar these three techniques are in measuring the oxygen used in the three different tissuesParticipants will: - Complete surveys, - Wear an activity tracker (7 days), - Undergo several non-invasive tests, and - Donate a blood sample The study will take place in UZ Brussel hospital and will take 2 study visits, approximately 7 days apart.
Not Provided
Individuals with long COVID:
Inclusion criteria:
- Long COVID diagnosis, based on the WHO definition;
- Presence of long COVID symptoms for a minimum of 6 months.
- History of confirmed or documented SARS-CoV-2 infection.
- Adult (≥18 years of age).
- Post-COVID-19 Functional Status Scale grade 2-4, while they had a grade 0 before the
SARS-CoV-2 infection.
Exclusion criteria:
- Pre-existing chronic diseases potentially affecting the functional status scale.
- Treatment with metabolism altering drugs.
- > 10 standard units of alcohol (10 grams of alcohol/glass) per week.
- Unable to understand oral and written instructions in Dutch, French or English.
- Allergies to medical adhesive bandages.
- Porphyria and other skin conditions aggravated by sunlight.
Convalescent individuals
Inclusion criteria:
- History of confirmed or documented SARS-CoV-2 infection.
- Complete recovery after the SARS-CoV-2 infection, no history of long COVID based on
the WHO definition;
- Post-COVID-19 Functional Status Scale [2] grade 0 both before the infection and
currently.
- Adult (≥18 years of age).
Exclusion criteria:
- Pre-existing chronic non-communicable diseases (e.g. hypertension, chronic
respiratory diseases, diabetes).
- Treatment with metabolism altering drugs.
- > 10 standard units of alcohol (10 grams of alcohol/glass) per week.
- Unable to understand oral and written instructions in Dutch, French or English.
- Allergies to medical adhesive bandages.
- Porphyria and other skin conditions aggravated by sunlight.
Laarbeeklaan 101
Jette 2794914, Brussels Capital 2800867, Belgium
Investigator: Berenice G. Jimenez Garcia, MSc.
Contact: +3224749624
berenice.gabriela.jimenez.garcia@vub.be
Berenice G. Jimenez Garcia, Master of Science
+3224749624
berenice.gabriela.jimenez.garcia@vub.be
Elisabeth De Waele, MD. PhD., Principal Investigator
Vitality Research Group, Metabolism and Nutrition, Vrije Universiteit Brussel (VUB), Clinical Nutrition Department, Universitair Ziekenhuis Brussel (UZ Brussel)