The goal of this observational study is to compare the immune function and infectionmechanism of patients with hematologic tumors and those people without underlyingdiseases after infection with SARS-CoV-2. Clinical characteristics, treatment options andresponses will be collected. Peripheral blood will be collected from patients withhematologic tumors infected with SARS-CoV-2 and those people without underlying diseasesinfected with SARS-CoV-2.
To establish a retrospective and prospective cohort of patients with hematologic tumors
infected with SARS-CoV-2 and people without underlying diseases infected with SARS-CoV-2.
Firstly, peripheral blood samples will be collected at infection time points and after
SARS-CoV-2 nucleic acid testing turns negative. Subsequently, the transcriptome
sequencing and immunological experiments will be performed to analyze the differentially
expressed genes, immune function of cells, etc.
Comparative analysis:
1. To compare the immune function of patients with hematologic tumors and those without
underlying diseases after infection with SARS-CoV-2.
2. The transcriptomic and proteomic changes of patients with hematologic tumors are
compared with those without underlying diseases after infection with SARS-CoV-2.
3. From the perspective of complex (human protein interaction subnetwork), the dynamic
change process of SARS-CoV-2-targeted human protein complex (periodic complex) was
deeply explored, in order to further analyze its potential dynamic infection
mechanism and provide new clues for the discovery of drug targets.
Other: None intervention
None intervention.
Inclusion Criteria:
- Clinical diagnosis of hematologic tumors Clinical diagnosis of SARS-CoV-2 infection
Exclusion Criteria:
- Severe diseases associated with other systems
Peking University First Hospital
Beijing, Beijing, China
Not Provided