The pharmacological treatment options in schizophrenia developing resistance to clozapineare limited. Few studies have found ECT as beneficial in TRS, including CRS. However,literature on the role of M-ECT in maintaining the therapeutic gains of acute ECT in CRSis lacking. The objective of the study is to compare the efficacy of M-ECT vsaripiprazole as an add-on to ongoing clozapine on the severity of symptom dimensions,cerebral perfusion, global functioning and cognitions in patients with CRS.
Not Provided
Procedure: maintenance ECT
Frequency of weekly sessions for 1 month, then fortnightly for 5 months
Drug: Aripiprazole tablet
Aripiprazole 10 mg in the morning throughout the study period
Inclusion Criteria:
1. Patients clinically diagnosed with CRS (currently under clozapine)
2. Patients aged 18-60 years of either sex.
3. LAR giving voluntary written consent for participation in the study
Exclusion Criteria:
1. Patient already on ECT or aripiprazole.
2. History of psychoactive substance abuse or dependence.
3. Co-morbid psychiatric, major medical or neurological disorders.
4. History of organicity or significant head injury.
5. Pacemaker or metal in any body part, excluding the mouth. Pregnant and breastfeeding
females.
Not Provided
Biswa Ranjan Mishra, MD
9438884220
psych_biswa@aiimsbhubaneswar.edu.in
Debadatta Mohapatra, MD
psych_debadatta@aiimsbhubaneswar.edu.in
Rituparna Maiti, MD, Study Director
AIIMS Bhubaneswar