Official Title
The Effectiveness of the Modified Thoracoabdominal Nerve Block Through Perichondrial Approach (M-TAPA) on Postoperative Analgesia and Recovery in Open-Heart Surgery: A Prospective, Double-Blind, Randomized Controlled Trial
Brief Summary

Postoperative pain following open-heart surgery is primarily caused by median sternotomy,although additional contributors include costovertebral joint stress related to sternalretraction and the presence of chest wall and mediastinal drains during the postoperativeperiod. This pain is often severe, especially in the early postoperative hours, makingeffective management both challenging and essential. Insufficient pain control frequentlynecessitates high doses of opioids, which may lead to adverse effects such as nausea,vomiting, respiratory complications, and postoperative delirium. Excessive use ofanesthetic agents or opioids can also delay extubation and prolong the process of weaningfrom mechanical ventilation.The modified thoracoabdominal nerve block through the perichondrial approach (M-TAPA) isa regional anesthesia technique performed beneath the costal margin between the internaloblique and transversus abdominis muscles. It provides broad dermatomal coverage,extending approximately from the upper thoracic to the lower thoracic and upper lumbarsegments. This study aims to evaluate the postoperative analgesic effectiveness ofcombining the M-TAPA block with a parasternal block in patients undergoing open-heartsurgery.

Detailed Description

Postoperative pain following open-heart surgery is primarily caused by median sternotomy,
although additional contributors include costovertebral joint stress related to sternal
retraction and the presence of chest wall and mediastinal drains during the postoperative
period. This pain is often severe, especially in the early postoperative hours, making
effective management both challenging and essential. Insufficient pain control frequently
necessitates high doses of opioids, which may lead to adverse effects such as nausea,
vomiting, respiratory complications, and postoperative delirium. Excessive use of
anesthetic agents or opioids can also delay extubation and prolong the process of weaning
from mechanical ventilation.

The modified thoracoabdominal nerve block through the perichondrial approach (M-TAPA) is
a regional anesthesia technique performed beneath the costal margin between the internal
oblique and transversus abdominis muscles. It provides broad dermatomal coverage,
extending approximately from the upper thoracic to the lower thoracic and upper lumbar
segments. This study aims to evaluate the postoperative analgesic effectiveness of
combining the M-TAPA block with a parasternal block in patients undergoing open-heart
surgery.

Not yet recruiting
Postoperative Pain
Acute Pain

Other: M TAPA block

In the M-TAPA group, the block will be performed preoperatively with the patient in the
supine position under ultrasound guidance using a high-frequency linear probe (GE
ML6-15-D Matrix Linear, Boston, USA) and an 80-mm block needle (Stimuplex Ultra®, Braun,
Melsungen, Germany). After identifying the appropriate plane between the transversus
abdominis muscle and the lower surface of the costal cartilage, 5 mL of saline will be
injected to confirm correct placement. Subsequently, 20 mL of 0.25% bupivacaine will be
injected bilaterally (a total of 40 mL for both sides).

Other: Parasternal blocks

Before intubation, the block will be performed under aseptic conditions using a
high-frequency ultrasound probe (GE ML6-15-D Matrix Linear, Boston, USA) placed
immediately lateral to the sternum after identifying the second to fourth intercostal
spaces. An 80-mm echogenic block needle (Stimuplex Ultra®, Braun, Melsungen, Germany)
will then be advanced using an in-plane approach from the skin toward the plane between
the pectoralis major and intercostal muscles. A total of 10 mL of 0.25% bupivacaine will
be injected bilaterally.

Other: Local infiltration

Local anesthetic infiltration (10 mL of 0.25% bupivacaine) will be administered around
the chest tube and mediastinal drain sites.

Eligibility Criteria

Inclusion Criteria:

- Patients aged 18 to 85 years with ASA physical status II-III who are scheduled to
undergo elective open-heart surgery will be included.

Exclusion Criteria:

Patients who refuse to participate in the study

Patients with coagulopathy

Patients with a history of allergy or toxicity to local anesthetics

Patients with hepatic or renal failure

Patients with uncontrolled diabetes mellitus

Patients with uncontrolled hypertension

Mentally disabled patients

Patients receiving chronic pain therapy (opioid use)

Patients using antidepressant medications

Patients with neuropathic pain

Patients with infection at the injection site

Pregnant, suspected pregnant, or breastfeeding women

Eligibility Gender
All
Eligibility Age
Minimum: 18 Years ~ Maximum: 85 Years
Locations

Not Provided

Contacts

Eralp Çevikkalp
+905054554875
eralpcevikkalp@hotmail.com

Emre ULUSOY
+905379492799
emreulusoy36@gmail.com

Not Provided

NCT Number
Keywords
m-tapa block
Open-heart surgery
parasternal block
postoperative analgesia
MeSH Terms
Pain, Postoperative
Acute Pain
Anesthesia, Local