Hospitalized patients with severe COVID-19 have an increased incidence of insulinresistance, impaired beta cell function, glucose intolerance (prediabetes), and overttype 2 diabetes (T2D) compared to non-hospitalized patients with COVID-19 and COVID-19negative individuals on long-term follow up.
The purpose of this research study is to understand the long-term effects of COVID-19
infection on individuals without any prior history of diabetes. This study will look at
several measures of diabetes, such as glycemic control (blood glucose/sugar levels),
function of beta cells (cells that make insulin to control sugar), insulin secretion and
insulin sensitivity (fasting insulin levels).
The following participants will be enrolled: 1) have had COVID-19 infection and were
hospitalized and recovered, or 2) have had mild COVID-19 infection and were seen at
outpatient clinics or ER and were not required to be hospitalized, or 3) have not had
COVID-19 infection but were seen in outpatient clinics or ER during the same time period.
The researchers hope to learn the long-term effects of COVID-19 infection in hospitalized
patients. Specifically, they will be focusing on the subsequent development of diabetes
and associated metabolic disturbances, such as impaired insulin secretion and insulin
resistance. A relationship between COVID-19 and diabetes needs to be investigated.
Other: Measure of physiologic parameters
Participants will have hepatic muscle and adipose tissue insulin sensitivity tested
Inclusion Criteria:
- Body Mass index (BMI) < 40 kg/m2
Exclusion Criteria:
- History of diabetes prior to SARS-CoV-2 infection
- Took medications used to treat diabetes prior to SARS-CoV-2 infection
- History of myocardial infarction or stroke within 6 months
- History of major organ system disease prior to COVID-19 infection
Texas Diabetes Institute - University Health System
San Antonio, Texas, United States
Investigator: Andrea Hansis-Diarte, MPh
Contact: 210-567-6691
hansisdiarte@uthscsa.edu
Marzieh Salehi, MD
(210) 567-6691
salehi@uthscsa.edu
Andrea Hansis Diarte, MPH
210-567-3208
hansisdiarte@uthscsa.edu
Ralph DeFronzo, MD, Principal Investigator
University of Texas Health Science Center San Antonio