Clarify the incidence of functional impairments in cured COVID-19 patients and identifyinfluencing factors. Build a multi-omics database for COVID-19 patients in the recoveryperiod to elucidate the biological biomarkers and targets associated with functionalimpairments. Comprehensive exploration of the long-term prognosis, complications,sequelae, and risk factors of COVID-19 patients after Omicron infection, as well as theirimmune characteristics. Compare the impact of different strains of the COVID-19 virus onprognosis and immune response. Develop comprehensive rehabilitation interventionstrategies for COVID-19 patients with functional impairments and evaluate the impact ofdifferent intervention methods on their prognosis. Based on clinical data, multi-omicsdata, and precise rehabilitation assessment data, construct predictive models forprognosis and rehabilitation effectiveness in COVID-19, providing scientific evidence forthe implementation of effective COVID-19 rehabilitation measures.
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Behavioral: respiratory rehabilitation
Emote respiratory rehabilitation:Patients wear monitoring devices and upload real-time
monitoring data such as vital signs through the FREE rehabilitation app installed on
their personal phones. Medical staff monitor changes in patients' vital signs in real
time through the FREE rehabilitation app on the medical end, and adjust respiratory
rehabilitation plans based on their phone or video guidance.
Outpatient respiratory rehabilitation:Traditional outpatient respiratory rehabilitation
is based on a group approach, with individualized intensity determined based on baseline
assessment results, and is conducted under supervision twice a week for a period of 12
weeks.
Inclusion Criteria:
1. Meets the diagnostic criteria for confirmed cases according to the "Diagnosis and
Treatment Protocol for Novel Coronavirus Pneumonia (Trial Version 10)";
2. The participant or the authorized representative understands the entire purpose of
the study, voluntarily participates in the research, and signs an informed consent
form, ensuring that they can complete regular assessments at the relevant
participating units and receive necessary rehabilitation treatment as required;
3. Agrees to the researcher's collection of their peripheral blood samples, saliva
samples, and urine samples for the needs of the study.
Exclusion Criteria:
1. Women who are pregnant or breastfeeding;
2. Individuals with mental disorders that affect normal communication;
3. Those who refuse to participate in regular assessments and rehabilitation
treatments;
4. Individuals who decline to provide specimens required for the study.
Beijing Institute of Respiratory Medicine
Beijing, Beijing, China
Investigator: Zhaohui Tong, Dr
Contact: +86 010 8523 1000
13910930309@163.com
Zhaohui Tong, Doctor
+86 139 1093 0309
13910930309@163.com
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