The goal of this observational study is to learn about the correlation between COVID-19and hyperthyroidism in Patients with hyperthyroidism complicated with COVID-19. The mainquestions it aims to answer are： - The main research object is Graves disease (GD) patients. - Changes of hyperthyroidism in GD patients complicated with COVID-19 - Changes of anxiety and depression in GD patients before and after SARS-CoV-2 infection. - The effect of psychological intervention in GD patients after COVID-19. Participants will have regular follow-upfor one year to hyperthyroidism in our hospital, and the investigators will collect the thyroid function and related examination indexes of patients in the corresponding time period.
Longitudinal analysis of GD status was performed: Three follow-up time points were
identified: before COVID-19, three months and one year after recovering from COVID-19
(the first follow-up visit, the second follow-up visit. Main collection items:
Hyperthyroidism symptoms, signs, hyperthyroidism complications, psychological evaluation
results, other complications，blood routine, liver and kidney function, thyroid function
(FT3, FT4, TSH), thyroid-related antibodies, glucose and lipid metabolism (FBG, HbA1c,
TC, TG, HDL-C, LDL-C), thyroid ultrasound and hyperthyroidism medication.Through this to
understand the changes of hyperthyroidism in HT patients complicated with COVID-19 and
the changes of anxiety and depression in hyperthyroidism patients before and after
SARS-CoV-2 infection.And the effect of psychological intervention in GD patients after
COVID-19.
Other: Thyroid metabolic index
The following indicators were collected from these patients: hyperthyroidism symptoms,
signs, hyperthyroidism complications, psychological evaluation results, other
complications，blood routine, liver and kidney function, thyroid function (FT3, FT4, TSH),
thyroid-related antibodies, glucose and lipid metabolism (FBG, HbA1c, TC, TG, HDL-C,
LDL-C), thyroid ultrasound and hyperthyroidism medication.
Psychological evaluations (using the 7-item Generalized Anxiety Disorder Questionnaire,
GAD-7, and the Patient Health Questionnaire 9, PHQ-9) and interventions.
Other Name: psychological evaluations,psychological interventions
Inclusion Criteria:
1. According to the diagnostic criteria of hyperthyroidism in the Chinese Guidelines
for the Diagnosis and Treatment of Thyroid Diseases formulated by the Chinese
Society of Endocrinology of the Chinese Medical Association, the patient had been
diagnosed with hyperthyroidism.
2. In accordance with the diagnostic criteria of "The diagnosis and Treatment Protocol
for novel coronavirus Infection (Trial version 10).
Exclusion Criteria:
1. Cases with incomplete data
2. Patients with severe autoimmune diseases, hematological diseases and malignant
tumors
3. Immunodeficiency (e.g.AIDS, long-term use of corticosteroids or other
immunosuppressive drugs leading to immunodeficiency)
4. Follow-up was less than 30 days
5. The results of thyroid function were less than 3 times
Qilu Hospital of Shandong University
Jinan, Shandong, China
Investigator: Kuanxiao Tang, M.D.
Contact: 18560082261
tangkx_ql@hotmail.com
Kuanxiao Tang, M.D.
18560082261
tangkx_ql@hotmail.com
Kuanxiao Tang, M.D., Principal Investigator
Qilu Hospital of Shandong University