Patients with post-Covid-19 syndrome are at high risk of developing cardiovasculardiseases 12 months after acute infection of COVID-19. We recently revealed that thesepatients have elevated muscular sympathetic nerve activity (MSNA), vascular dysfunction,impaired cardiac diastolic function, and reduced functional capacity. Considering thatthese outcomes are independent predictors of cardiovascular mortality, it is urgent torestore the cardiovascular health of these patients. High resistance inspiratory musclestrength training (IMST) at 75% of pressure inspiratory (PImax) performed at home (5min/session, 5-7 times/week per 6 weeks) reduces the MSNA, improves the endothelialfunction and lowers blood pressure in different populations. Based on these findings,IMST (75% PImax) is an excellent therapeutic option for patients with post-COVID-19syndrome. Therefore, the aim of the present proposal is to test whether IMST (75% PImax)reduces sympathetic activity, improves vascular function, and restores cardiac function,evoking an increase in functional capacity in patients with post-COVID-19 syndrome. Totest these hypotheses we will conduct a randomized, double-blind, sham-controlledclinical trial to test these hypotheses.